Rho Kinase Inhibitor II CAS: 97627-27-5
MF: C12H8Cl3N3O
MW: 316.57
An inhibitor of Rho-associated protein kinase.

Rho Kinase Inhibitor II (CAS 97627-27-5)

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Alternate Names: N-(4-Pyridyl)-N'-(2,4,6-trichlorophenyl)urea
Application: Rho Kinase Inhibitor II is an inhibitor of Rho-associated protein kinase
CAS Number: 97627-27-5
Molecular Weight: 316.57
Molecular Formula: C12H8Cl3N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Rho Kinase Inhibitor II is a pyridyl urea compound that acts as a potent, selective, and ATP-competitive inhibitor of Rock (Rho-associated protein kinase). The compound displays little activity towards Erk, PKA, PKC, PDGFR, or c-Kit/SCFR.


References

Takami, A., et al. 2004. Bioorg. Med. Chem. 12, 2115.

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml).
Storage :
Store at 4° C
Melting Point :
184.58° C (Predicted)
Boiling Point :
~351.5° C at 760 mmHg (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.71 (Predicted)
IC50 :
ROCK: IC50 = 0.2 µM
pK Values :
pKa: 11.1 (Predicted), pKb: 5.92 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760634
MDL Number :
MFCD08702695
SMILES :
C1=CN=CC=C1NC(=O)NC2=C(C=C(C=C2Cl)Cl)Cl

Download SDS (MSDS)

Certificate of Analysis

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