Rho Kinase Inhibitor II (CAS 97627-27-5)
QUICK LINKS
Rho Kinase Inhibitor II is a compound that functions as a potent and selective inhibitor of Rho-associated protein kinase (ROCK). It exerts its mode of action by specifically targeting the ATP-binding site of ROCK, thereby inhibiting its activity. This inhibition leads to the suppression of ROCK-mediated signaling pathways, which are involved in the regulation of actin cytoskeleton dynamics, cell adhesion, and smooth muscle contraction. By interfering with ROCK activity, Rho Kinase Inhibitor II disrupts the downstream cellular processes that are dependent on ROCK signaling, ultimately impacting cellular morphology and motility. This compound′s ability to modulate ROCK activity makes it useful for investigating the molecular mechanisms underlying ROCK-mediated cellular functions in various experimental contexts.
Rho Kinase Inhibitor II (CAS 97627-27-5) References
- Rho kinase activates ezrin-radixin-moesin (ERM) proteins and mediates their function in cortical neuron growth, morphology and motility in vitro. | Haas, MA., et al. 2007. J Neurosci Res. 85: 34-46. PMID: 17075902
- ERM proteins mediate the effects of Na+/H+ exchanger (NHE1) activation in cardiac myocytes. | Darmellah, A., et al. 2009. Cardiovasc Res. 81: 294-300. PMID: 19028724
- Cocaine regulates ezrin-radixin-moesin proteins and RhoA signaling in the nucleus accumbens. | Kim, WY., et al. 2009. Neuroscience. 163: 501-5. PMID: 19580848
- Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis. | Parisiadou, L., et al. 2009. J Neurosci. 29: 13971-80. PMID: 19890007
- RhoA/Rho-kinase: pathophysiologic and therapeutic implications in gastrointestinal smooth muscle tone and relaxation. | Rattan, S., et al. 2010. Gastroenterology. 138: 13-8.e1-3. PMID: 19931260
- ROCK suppression promotes differentiation and expansion of endothelial cells from embryonic stem cell-derived Flk1(+) mesodermal precursor cells. | Joo, HJ., et al. 2012. Blood. 120: 2733-44. PMID: 22896004
- CCL2/CCR2 chemokine signaling coordinates survival and motility of breast cancer cells through Smad3 protein- and p42/44 mitogen-activated protein kinase (MAPK)-dependent mechanisms. | Fang, WB., et al. 2012. J Biol Chem. 287: 36593-608. PMID: 22927430
- Protein kinases: master regulators of neuritogenesis and therapeutic targets for axon regeneration. | Bennison, SA., et al. 2020. Cell Mol Life Sci. 77: 1511-1530. PMID: 31659414
- ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway. | Moskal, N., et al. 2020. Nat Commun. 11: 88. PMID: 31900402
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rho Kinase Inhibitor II, 5 mg | sc-222253 | 5 mg | $152.00 |