Rheumatoid Factor Antibody (005): sc-59352
- Rheumatoid Factor Antibody (005) is a mouse monoclonal IgM Rheumatoid Factor antibody provided at 100 µl ascites
- raised against Rheumatoid Factor of human origin
- recommended for detection of human Rheumatoid Factor of human origin by ELISA; may cross-react with IgM-RF paraproteins from unrelated individuals
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Rheumatoid Factor Antibody (005). This work is in progress.
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Rheumatoid Factor Antibody (005) is a mouse monoclonal IgM antibody that detects Rheumatoid Factor of human origin by enzyme-linked immunosorbent assay (ELISA). Anti-Rheumatoid Factor antibody (005) is available as a non-conjugated isotype antibody. Rheumatoid Factor is an antibody that specifically recognizes the Fc portion of immunoglobulin G (IgG), and Rheumatoid Factor presence is crucial for understanding various autoimmune conditions. The formation of immune complexes between Rheumatoid Factor and IgG can trigger a cascade of inflammatory responses, which are significant in the pathology of diseases such as rheumatoid arthritis and Sjogren′s syndrome. Elevated Rheumatoid Factor levels in the bloodstream are clinically relevant, serving as biomarkers for these conditions, indicating not only joint inflammation but also a propensity for systemic manifestations, including rheumatoid nodules and lung complications. Accurate measurement of Rheumatoid Factor levels through enzyme-linked immunosorbent assay (ELISA) is essential for diagnosing and monitoring these autoimmune disorders, making Rheumatoid Factor (005) antibody a valuable tool in clinical and research settings.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Rheumatoid Factor Antibody (005) References:
- Salivary gland lymphomas in patients with Sjögren's syndrome may frequently develop from rheumatoid factor B cells. | Martin, T., et al. 2000. Arthritis Rheum. 43: 908-16. PMID: 10765938
- [A comparison of two tests for rheumatoid factor: latex test and l-agglutination (author's transl)]. | Gawlitza, G. and Wigand, R. 1976. Immun Infekt. 4: 23-8. PMID: 1254316
- Rheumatoid factor and anticitrullinated protein antibodies in rheumatoid arthritis: diagnostic value, associations with radiological progression rate, and extra-articular manifestations. | De Rycke, L., et al. 2004. Ann Rheum Dis. 63: 1587-93. PMID: 15547083
- Rheumatoid factor accentuation of pulmonary lesions associated with experimental diffuse proliferative lung disease. | DeHoratius, RJ. and Williams, RC. 1972. Arthritis Rheum. 15: 293-301. PMID: 4555645
- Rheumatoid factor isotypes in serum and salivary fluid of patients with primary Sjögren's syndrome. | Markusse, HM., et al. 1993. Clin Immunol Immunopathol. 66: 26-32. PMID: 8440071
- Binding specificities of a polyreactive and a monoreactive human monoclonal IgG rheumatoid factor: role of oligosaccharides. | al-Balaghi, S., et al. 1996. Scand J Immunol. 44: 470-7. PMID: 8947598
- Rheumatoid factor autoantibodies in health and disease. | Mageed, RA., et al. 1997. Ann N Y Acad Sci. 815: 296-311. PMID: 9186666
- IgG and IgM rheumatoid factor in active seronegative nodular rheumatoid arthritis and in children with benign rheumatoid nodules. | Robbins, DL., et al. 1982. Clin Rheumatol. 1: 104-11. PMID: 6926807
- Rheumatoid factor diversity. | Koopman, WJ. and Schrohenloher, RE. 1988. In Vivo. 2: 73-7. PMID: 2979820
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rheumatoid Factor Antibody (005) | sc-59352 | 100 µl ascites | $322.00 |