RHBDL1 Antibody (5B11): sc-517160
- RHBDL1 Antibody (5B11) is a mouse monoclonal IgG1 κ RHBDL1 antibody provided at 100 µg/ml
- raised against amino acids 1-100 representing partial length RHBDL1 of human origin
- recommended for detection of RHBDL1 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for RHBDL1 Antibody (5B11). This work is in progress.
RHBDL1 Antibody (5B11) is a mouse monoclonal IgG1 kappa light chain antibody that detects RHBDL1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-RHBDL1 antibody (5B11) is available as a non-conjugated format. RHBDL1, or rhomboid-related protein 1, is a crucial intramembrane serine protease that plays a significant role in regulating various cellular processes by cleaving type-1 transmembrane domains. RHBDL1 is composed of 438 amino acids and is characterized by a multi-pass membrane structure, essential for enzymatic activity. The catalytic mechanism of RHBDL1 involves a dyad of serine and histidine residues derived from different transmembrane domains, allowing effective substrate processing within the lipid bilayer. RHBDL1 expression occurs in vital tissues such as heart, brain, skeletal muscle, and kidney, where RHBDL1 influences signaling pathways related to growth factors and cellular communication. RHBDL1 can exist in two isoforms due to alternative splicing, which may further diversify functional roles in human physiology. The gene encoding RHBDL1 is located on human chromosome 16p13.3, highlighting genetic significance in health and disease.
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RHBDL1 Antibody (5B11) References:
- Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. | Urban, S., et al. 2001. Cell. 107: 173-82. PMID: 11672525
- A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands. | Urban, S., et al. 2002. EMBO J. 21: 4277-86. PMID: 12169630
- Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain. | Urban, S. and Freeman, M. 2003. Mol Cell. 11: 1425-34. PMID: 12820957
- Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2. | Pascall, JC. and Brown, KD. 2004. Biochem Biophys Res Commun. 317: 244-52. PMID: 15047175
- Rhomboid proteins: conserved membrane proteases with divergent biological functions. | Urban, S. 2006. Genes Dev. 20: 3054-68. PMID: 17114579
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RHBDL1 Antibody (5B11) | sc-517160 | 100 µg/ml | $322.00 |