RG-7112 (CAS 939981-39-2)
CAS Number:
939981-39-2
Molecular Weight:
727.8
Molecular Formula:
C38H48Cl2N4O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
RG-7112 (CAS 939981-39-2) References
- Initial testing of the MDM2 inhibitor RG7112 by the Pediatric Preclinical Testing Program. | Carol, H., et al. 2013. Pediatr Blood Cancer. 60: 633-41. PMID: 22753001
- Activation of p53 by the MDM2 inhibitor RG7112 impairs thrombopoiesis. | Iancu-Rubin, C., et al. 2014. Exp Hematol. 42: 137-45.e5. PMID: 24309210
- Identification of High Affinity Non-Peptidic Small Molecule Inhibitors of MDM2-p53 Interactions through Structure-Based Virtual Screening Strategies. | Bandaru, S., et al. 2015. Asian Pac J Cancer Prev. 16: 3759-65. PMID: 25987034
- RG7112, a small-molecule inhibitor of MDM2, enhances trabectedin response in soft tissue sarcomas. | Obrador-Hevia, A., et al. 2015. Cancer Invest. 33: 440-50. PMID: 26288114
- Preclinical Efficacy of the MDM2 Inhibitor RG7112 in MDM2-Amplified and TP53 Wild-type Glioblastomas. | Verreault, M., et al. 2016. Clin Cancer Res. 22: 1185-96. PMID: 26482041
- MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification. | Kwon, DH., et al. 2016. Nat Commun. 7: 10492. PMID: 26832969
- In Vitro Characterization of a Potent p53-MDM2 Inhibitor, RG7112 in Neuroblastoma Cancer Cell Lines. | Al-Ghabkari, A. and Narendran, A. 2019. Cancer Biother Radiopharm. 34: 252-257. PMID: 30724592
- Senotherapeutic drugs for human intervertebral disc degeneration and low back pain. | Cherif, H., et al. 2020. Elife. 9: PMID: 32821059
- Cell cycle block by p53 activation reduces SARS-CoV-2 release in infected alveolar basal epithelial A549-hACE2 cells. | Lodi, G., et al. 2022. Front Pharmacol. 13: 1018761. PMID: 36582523
- Senolytic Combination Treatment Is More Potent Than Single Drugs in Reducing Inflammatory and Senescence Burden in Cells from Painful Degenerating IVDs. | Mannarino, M., et al. 2023. Biomolecules. 13: PMID: 37627322
Inhibitor of:
53BP2, LOC646012, MDM-2, MDM2, NSE4A, and Trp53i13.Activator of:
p53, and p53AIP1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RG-7112, 10 mg | sc-507292 | 10 mg | $520.00 |