Molecular structure of RG-13022, CAS Number: 136831-48-6
RG-13022 (CAS 136831-48-6)
See product citations (1)
Application:
RG-13022 is an inhibitor of the EGF and PDGF receptor tyrosine kinases
CAS Number:
136831-48-6
Purity:
≥98%
Molecular Weight:
266.3
Molecular Formula:
C16H14N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
RG-13022 is a Tyrosine kinase tyrphostin. Reports indicate that RG-13022 suppresses epidermal growth factor (EGF)-stimulated cancer cell proliferation in cancer cell studies. Additionally, RG-13022 has been described to inhibit EGF, platelet-dervied growth (PDGF) signaling, and PDGF enhanced DNA synthesis. RG-13022 is an inhibitor of EGFR and PDGFR.
RG-13022 (CAS 136831-48-6) References
- Mitogen-activated protein kinase (MAPK) regulates the expression of progelatinase B (MMP-9) in breast epithelial cells. | Reddy, KB., et al. 1999. Int J Cancer. 82: 268-73. PMID: 10389762
- Transforming growth factor-alpha stimulates proliferation of mammotrophs and corticotrophs in the mouse pituitary. | Oomizu, S., et al. 2000. J Endocrinol. 165: 493-501. PMID: 10810313
- Cell signaling pathways mediating epidermal growth factor stimulation of Na:K:2Cl cotransport activity in rabbit corneal epithelial cells. | Yang, H., et al. 2001. J Membr Biol. 183: 93-101. PMID: 11562791
- Intrapituitary regulatory system of mammotrophs in the mouse. | Takahashi, S., et al. 2002. Arch Physiol Biochem. 110: 34-41. PMID: 11935398
- Epidermal growth factor and transforming growth factor-alpha stimulate the proliferation of mouse uterine stromal cells. | Komatsu, N., et al. 2003. Zoolog Sci. 20: 639-45. PMID: 12777835
- The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice. | Yoneda, T., et al. 1991. Cancer Res. 51: 4430-5. PMID: 1651159
- Growth inhibition of gastric cancer cell lines by the tyrphostin RG13022 and its effects on intracellular signalling. | McLaughlin, M., et al. 1996. Int J Oncol. 8: 589-96. PMID: 21544401
- Antiproliferative effect of tyrosine kinase inhibitors in epidermal growth factor-stimulated growth of human gastric cancer cells. | Piontek, M., et al. 1993. Anticancer Res. 13: 2119-23. PMID: 8297123
- Activation of the epidermal growth factor receptor by skin tumor promoters and in skin tumors from SENCAR mice. | Xian, W., et al. 1995. Cell Growth Differ. 6: 1447-55. PMID: 8562483
- Inhibitors of protein tyrosine phosphorylation reduce the proliferation of two human glioma cell lines. | Oude Weernink, PA., et al. 1996. Neurosurgery. 38: 108-13; discussion 113-4. PMID: 8747958
- Epidermal growth factor-induced apoptosis in A431 cells can be reversed by reducing the tyrosine kinase activity. | Gulli, LF., et al. 1996. Cell Growth Differ. 7: 173-8. PMID: 8822200
- In vivo pharmacology and anti-tumour evaluation of the tyrphostin tyrosine kinase inhibitor RG13022. | McLeod, HL., et al. 1996. Br J Cancer. 74: 1714-8. PMID: 8956783
- Mitogen-activated protein kinase is involved in epidermal-growth-factor-regulated protein phosphorylation in nuclear membranes isolated from JEG-3 human choriocarcinoma cells. | Bian, L., et al. 1998. Eur J Biochem. 253: 545-51. PMID: 9654049
Inhibitor of:
EGFR, PDGFR, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RG-13022, 5 mg | sc-200591 | 5 mg | $95.00 | |||
RG-13022, 10 mg | sc-200591A | 10 mg | $175.00 |