Reveromycin A CAS: 134615-37-5
MF: C36H52O11
MW: 660.8
A spiroketal antibiotic inhibitor of EGF mitogenic activity.

Reveromycin A (CAS 134615-37-5)

Reveromycin A | CAS 134615-37-5 is rated 5.0 out of 5 by 1.
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Application: Reveromycin A is a spiroketal antibiotic inhibitor of EGF mitogenic activity
CAS Number: 134615-37-5
Purity: >99%
Molecular Weight: 660.8
Molecular Formula: C36H52O11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Reveromycin A, the dominant analogue of a complex of spiroketals isolated from a Streptomyces sp., is an inhibitor of the mitogenic activity of EGF (epidermal growth factor). It is a G1 phase cell cycle inhibitor, selectively inhibiting IleRS (isoleucyl-tRNA synthetase). Reveromycin A displays antiproliferative behaviour against human cell lines KB and K562, as well as potent antifungal activity. More recently it has been shown to induce apoptosis in osteoclasts thus inhibiting bone resorption.


References

1. Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Woo J.T. et al. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 4729. 2. Reveromycin A inhibits osteolytic bone metastasis of small-cell lung cancer cells, SBC-5, through an antiosteoclastic activity. Muguruma H. et al. Clin. Cancer Res. 2005, 11, 8822. 3. Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A. Miyamoto Y. et al. J. Biol. Chem. 2002, 277, 28810. 4. Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities. Takahashi H. et al. J. Antibiot. 1992, 45, 1414.

Appearance :
Lyophilized
Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in ethyl acetate, ethanol, methanol, DMF, and DMSO.
Storage :
Store at -20° C
Boiling Point :
849.02° C at 760 mmHg (Predicted)
Density :
1.22 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
IleRS: IC50 = 1.97 nM (rat); IleRS: IC50 = 4.46 nM (human); NRK: EC5050 = 2.39 µM (rat)
pK Values :
pKa: 4.36 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00912537
SMILES :
CCCCC1(CCC2(CCC(C(O2)CC=C(C)C=CC(C(C)C=CC(=O)O)O)C)OC1C=CC(=CC(=O)O)C)OC(=O)CCC(=O)O

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Certificate of Analysis

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Reveromycin A (CAS 134615-37-5)  Product Citations

See how others have used Reveromycin A (CAS 134615-37-5). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 18840695  Yano, A. et al. 2008. Proc. Natl. Acad. Sci. U.S.A. 105: 15541-15546.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Yano Yano, A. et al. (PubMed 18840695) found that 17-AAG promotes osteoclastogenesis in vitro by transiently stimulating a signaling cascade beginning with Src kinase and proceeding to Akt, however this process can be reversed by the osteoclast-specific apoptosis inducer Reveromycin A (sc-202314). -SCBT Publication Review
Date published: 2015-06-19
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