Date published: 2025-10-16

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Retinyl palmitate (CAS 79-81-2)

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Alternate Names:
Vitamin A palmitate; Retinyl hexadecanoate; Aquasol A
Application:
Retinyl palmitate is an analog of vitamin A with antiproliferative effects
CAS Number:
79-81-2
Purity:
≥90%
Molecular Weight:
524.86
Molecular Formula:
C36H60O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Retinyl palmitate is a vitamin A analog that inhibits cell proliferation and induces cell differentiation. It is metabolized to form retinoic acid, which is an active form of vitamin A. Retinoic acid is known to bind to nuclear receptors, which results in the activation of various genes and pathways, leading to the biological effects of vitamin A. Retinyl palmitate is known to be involved in the regulation of gene expression, cell growth, cell differentiation, and immune system function. It is employed in scientific research studies related to these topics, as well as the development and maintenance of healthy skin, eyesight, and other bodily functions.


Retinyl palmitate (CAS 79-81-2) References

  1. Retinyl palmitate and the blue-light-induced phototoxicity of human ocular lipofuscin.  |  Lamb, LE., et al. 2001. Arch Biochem Biophys. 393: 316-20. PMID: 11556819
  2. Levels of retinyl palmitate and retinol in the skin of SKH-1 mice topically treated with retinyl palmitate and concomitant exposure to simulated solar light for thirteen weeks.  |  Yan, J., et al. 2007. Toxicol Ind Health. 23: 581-9. PMID: 18717516
  3. Retinyl palmitate flexible polymeric nanocapsules: characterization and permeation studies.  |  Teixeira, Z., et al. 2010. Colloids Surf B Biointerfaces. 81: 374-80. PMID: 20655183
  4. Chronic retinyl palmitate supplementation to middle-aged Wistar rats disrupts the brain redox homeostasis and induces changes in emotional behavior.  |  Schnorr, CE., et al. 2015. Mol Nutr Food Res. 59: 979-90. PMID: 25676740
  5. Cytogenotoxicological defense of retinyl palmitate in the front damage of antineoplastics.  |  de Carvalho, RM., et al. 2017. Exp Toxicol Pathol. 69: 293-297. PMID: 28216169
  6. Efect of vitamin A suplementation: a systematic review.  |  Soares, MM., et al. 2019. Cien Saude Colet. 24: 827-838. PMID: 30892504
  7. Epidermal Delivery of Retinyl Palmitate Loaded Transfersomes: Penetration and Biodistribution Studies.  |  Pena-Rodríguez, E., et al. 2020. Pharmaceutics. 12: PMID: 32019144
  8. Microencapsulation of retinyl palmitate by melt dispersion for cosmetic application.  |  Nandy, A., et al. 2020. J Microencapsul. 37: 205-219. PMID: 32039634
  9. Nanoemulgel for Improved Topical Delivery of Retinyl Palmitate: Formulation Design and Stability Evaluation.  |  Algahtani, MS., et al. 2020. Nanomaterials (Basel). 10: PMID: 32353979
  10. The vitamin A ester retinyl propionate has a unique metabolic profile and higher retinoid-related bioactivity over retinol and retinyl palmitate in human skin models.  |  Bjerke, DL., et al. 2021. Exp Dermatol. 30: 226-236. PMID: 33098193
  11. Microbial Production of Retinyl Palmitate and Its Application as a Cosmeceutical.  |  Choi, BH., et al. 2020. Antioxidants (Basel). 9: PMID: 33202630
  12. Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study.  |  Salem, HF., et al. 2021. Int J Nanomedicine. 16: 4251-4276. PMID: 34211271
  13. Rapid direct analysis of retinyl palmitate (vitamin A) in fortified vegetable oils by HPLC-FLD.  |  Rimkus, GG., et al. 2022. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 39: 24-34. PMID: 34587464
  14. Darier disease successfully treated with a topical agent containing vitamin A (retinyl palmitate), vitamin E, and urea.  |  Miyazaki, A., et al. 2022. J Dermatol. 49: 779-782. PMID: 35437850
  15. Retinyl palmitate reduces hepatic fibrosis in rats induced by dimethylnitrosamine or pig serum.  |  Mizobuchi, Y., et al. 1998. J Hepatol. 29: 933-43. PMID: 9875640

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Retinyl palmitate, 25 g

sc-205836
25 g
$204.00

Retinyl palmitate, 100 g

sc-205836A
100 g
$787.00

Retinyl palmitate, 1 kg

sc-205836B
1 kg
$1500.00