Molecular structure of Reticulol, CAS Number: 26246-41-3
Reticulol (CAS 26246-41-3)
Application:
Reticulol is an isocoumarin metabolite shown to inactivate topoisomerase I
CAS Number:
26246-41-3
Purity:
>95%
Molecular Weight:
222.2
Molecular Formula:
C11H10O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Reticulol acts as an isocoumarin metabolite that is produced by certain species of Streptomyces. It was first described as a potent inhibitor of cyclic nucleotide PDE (phosphodiesterase). Recent research shows Reticulol exhibits a Topo I (topoisomerase I) inactivation mechanism. It has been reported to cause inhibition of lung metastasis in the B16F10 melanoma model in a dose dependent manner.
Reticulol (CAS 26246-41-3) References
- Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma. | Lim, DS., et al. 2003. Chemotherapy. 49: 146-53. PMID: 12815208
- Topoisomerase I inactivation by reticulol and its in vivo cytotoxicity against B16F10 melanoma. | Lim, DS., et al. 2003. Chemotherapy. 49: 257-63. PMID: 14504438
- Reticulol, an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. | Furutani, Y., et al. 1975. J Antibiot (Tokyo). 28: 558-60. PMID: 168174
- Reticulone, a novel free radical scavenger produced by Aspergillus sp. | Ryoo, IJ., et al. 2009. J Microbiol Biotechnol. 19: 1573-5. PMID: 20075621
- Bireticulol, a bioactive isocoumarin dimer from Streptomyces sp. BCC24731. | Boonlarppradab, C., et al. 2011. J Antibiot (Tokyo). 64: 267-70. PMID: 21224860
- New isocoumarin derivatives and meroterpenoids from the marine sponge-associated fungus Aspergillus similanensis sp. nov. KUFA 0013. | Prompanya, C., et al. 2014. Mar Drugs. 12: 5160-73. PMID: 25317534
- Polyketides from the Deep-Sea-Derived Fungus Graphostroma sp. MCCC 3A00421 Showed Potent Antifood Allergic Activities. | Niu, S., et al. 2018. J Agric Food Chem. 66: 1369-1376. PMID: 29355320
- Reticulol, a new metabolic isocoumarin. | Mitscher, LA., et al. 1964. Experientia. 20: 258-9. PMID: 5856305
Inhibitor of:
PDE, and Topo I.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Reticulol, 250 µg | sc-202313 | 250 µg | $100.00 | |||
Reticulol, 1 mg | sc-202313A | 1 mg | $213.00 |