Respiratory Syncytial Virus Antibody (8B10): sc-52181
- Respiratory Syncytial Virus Antibody (8B10) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against purified respiratory syncytial virus, strain Long
- recommended for detection of nucleoprotein of RSV of Respiratory Syncytial Virus origin by IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Respiratory Syncytial Virus Antibody (8B10). This work is in progress.
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Respiratory Syncytial Virus Antibody (8B10) is a mouse monoclonal IgG1 antibody that specifically detects Respiratory Syncytial Virus (RSV) by immunofluorescence (IF). RSV is a significant pathogen, particularly in infants and young children, leading to severe respiratory illnesses. Anti-RSV antibody (8B10) recognizes the fusion protein of the RSV strain RSS 2 (subtype A), which is crucial for viral infection of host cells by mediating the fusion of viral and cellular membranes, allowing virus penetration into the host cell. This process facilitates viral entry and contributes to syncytia formation, creating multi-nucleated giant cells that disrupt normal tissue function and worsen respiratory distress. The matrix protein assists in viral assembly and regulates viral component trafficking within host cells, while inhibiting host transcription - a mechanism potentially crucial in RSV-caused respiratory disease pathogenesis. RSV monoclonal antibody (8B10) serves as an essential tool for studying RSV infection mechanisms and respiratory health impacts.
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Respiratory Syncytial Virus Antibody (8B10) References:
- Respiratory syncytial virus infection and bronchiolitis. | Piedimonte, G. and Perez, MK. 2014. Pediatr Rev. 35: 519-30. PMID: 25452661
- Respiratory Syncytial Virus Bronchiolitis in Children. | Smith, DK., et al. 2017. Am Fam Physician. 95: 94-99. PMID: 28084708
- Vaccine development for respiratory syncytial virus. | Graham, BS. 2017. Curr Opin Virol. 23: 107-112. PMID: 28525878
- Molecular epidemiology of respiratory syncytial virus. | Pangesti, KNA., et al. 2018. Rev Med Virol. 28: PMID: 29377415
- Respiratory syncytial virus entry and how to block it. | Battles, MB. and McLellan, JS. 2019. Nat Rev Microbiol. 17: 233-245. PMID: 30723301
- Respiratory syncytial virus infection in adults. | Nam, HH. and Ison, MG. 2019. BMJ. 366: l5021. PMID: 31506273
- The journey to a respiratory syncytial virus vaccine. | Mejias, A., et al. 2020. Ann Allergy Asthma Immunol. 125: 36-46. PMID: 32217187
- IGF1R is an entry receptor for respiratory syncytial virus. | Griffiths, CD., et al. 2020. Nature. 583: 615-619. PMID: 32494007
- Preventing respiratory syncytial virus bronchiolitis in infants. | Robinson, E. and Smyth, RL. 2023. BMJ. 381: 1023. PMID: 37164384
- Respiratory Syncytial Virus in Pregnancy: An Obstetrics View. | Dominoni, M., et al. 2024. Pediatr Rep. 16: 921-924. PMID: 39449405
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Respiratory Syncytial Virus Antibody (8B10) | sc-52181 | 100 µg/ml | $316.00 |