Reptin 52 Antibody (42): sc-136058
- Reptin 52 Antibody (42) is a mouse monoclonal IgG1, cited in 2 publications, provided at 50 µg/0.5 ml
- raised against amino acids 180-228 of Reptin 52 of human origin
- recommended for detection of Reptin 52 of mouse, rat, human and canine origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Reptin 52 Antibody (42). This work is in progress.
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Reptin 52 Antibody (42) is a mouse monoclonal IgG1 antibody that detects Reptin 52 in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Reptin 52, also known as RUVBL2, is a vital nuclear protein that plays a significant role in various cellular processes, including transcriptional regulation and chromatin remodeling. Reptin 52 is primarily located in the nucleus, where anti-Reptin 52 antibody (42) can detect multiprotein complexes that modulate gene expression. Reptin 52′s nuclear localization enables interaction with key transcription factors, such as Myc and Pontin 52, facilitating their oncogenic functions. This interaction regulates genes involved in cell proliferation and survival, making Reptin 52 a significant player in cancer biology. Reptin 52 undergoes post-translational modifications, including phosphorylation and acetylation, which can influence activity and interactions with other proteins. Reptin 52 (42) monoclonal antibody provides a reliable tool for researchers studying cellular signaling pathways and implications in oncogenesis.
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Reptin 52 Antibody (42) References:
- AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay. | Izumi, N., et al. 2010. Sci Signal. 3: ra27. PMID: 20371770
- Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2. | Izumi, N., et al. 2012. Nucleus. 3: 29-43. PMID: 22540023
- Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM. | Muñoz-Hernández, H., et al. 2019. Sci Adv. 5: eaaw1616. PMID: 31049401
- Multilevel regulation of RUVBL2 expression predicts poor prognosis in hepatocellular carcinoma. | Yan, T., et al. 2019. Cancer Cell Int. 19: 249. PMID: 31572066
- PPARγ enhanced Adiponectin polymerization and trafficking by promoting RUVBL2 expression during adipogenic differentiation. | Zhu, D., et al. 2021. Gene. 764: 145100. PMID: 32877748
- Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM. | López-Perrote, A., et al. 2020. Elife. 9: PMID: 33205750
- Novel HIF-2α interaction with Reptin52 impairs HIF-2 transcriptional activity and EPO secretion. | Gkotinakou, IM., et al. 2021. Biochem Biophys Res Commun. 557: 143-150. PMID: 33865222
- Deciphering cellular and molecular determinants of human DPCD protein in complex with RUVBL1/RUVBL2 AAA-ATPases. | Dos Santos Morais, R., et al. 2022. J Mol Biol. 434: 167760. PMID: 35901867
- The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors. | Wang, H., et al. 2022. Nat Commun. 13: 5703. PMID: 36171202
- Paraventricular hypothalamic RUVBL2 neurons suppress appetite by enhancing excitatory synaptic transmission in distinct neurocircuits. | Xing, M., et al. 2024. Nat Commun. 15: 8939. PMID: 39414808
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Reptin 52 Antibody (42) | sc-136058 | 50 µg/0.5 ml | $316.00 |