Molecular structure of Repaglinide, CAS Number: 135062-02-1
Repaglinide (CAS 135062-02-1)
See product citations (3)
Alternate Names:
(S)-2-Ethoxy-4-[2-[[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic Acid
Application:
Repaglinide is a KIR6 (KATP) channel blocker
CAS Number:
135062-02-1
Purity:
≥98%
Molecular Weight:
452.59
Molecular Formula:
C27H36N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Repaglinide is a non-sulfonylurea insulin secretagogue that functions by specifically targeting the pancreatic beta cells to stimulate insulin release. Repaglinide acts by binding to the ATP-sensitive potassium channels on the beta cell membrane, leading to depolarization and subsequent calcium influx. This increase in intracellular calcium triggers the exocytosis of insulin-containing granules, resulting in the release of insulin into the bloodstream. By modulating the activity of these potassium channels, repaglinide effectively promotes insulin secretion in response to glucose levels, thereby aiding in the regulation of blood sugar levels.
Repaglinide (CAS 135062-02-1) References
- Effect of the CYP2C8 genotype on the pharmacokinetics and pharmacodynamics of repaglinide. | Tomalik-Scharte, D., et al. 2011. Drug Metab Dispos. 39: 927-32. PMID: 21270106
- Repaglinide-loaded solid lipid nanoparticles: effect of using different surfactants/stabilizers on physicochemical properties of nanoparticles. | Ebrahimi, HA., et al. 2015. Daru. 23: 46. PMID: 26392174
- Identification of repaglinide as a therapeutic drug for glioblastoma multiforme. | Xiao, ZX., et al. 2017. Biochem Biophys Res Commun. 488: 33-39. PMID: 28476618
- Design and Development of Repaglinide Microemulsion Gel for Transdermal Delivery. | Shinde, UA., et al. 2018. AAPS PharmSciTech. 19: 315-325. PMID: 28717973
- Characteristics of repaglinide effects on insulin secretion. | Takahashi, H., et al. 2018. Eur J Pharmacol. 828: 52-59. PMID: 29555503
- Repaglinide inhibits cyclosporine A-induced renal tubular toxicity by affecting apoptosis and Bax and Bcl-2 expression. | Li, J., et al. 2018. Turk J Med Sci. 48: 880-885. PMID: 30121055
- Repaglinide-loaded nanostructured lipid carriers with different particle sizes for improving oral absorption: preparation, characterization, pharmacokinetics, and in situ intestinal perfusion. | Wu, L., et al. 2020. Drug Deliv. 27: 400-409. PMID: 31729898
- Repaglinide Silences the FOXO3/Lumican Axis and Represses the Associated Metastatic Potential of Neuronal Cancer Cells. | Salcher, S., et al. 2019. Cells. 9: PMID: 31861249
- Acarbose versus Repaglinide in Diabetes Treatment: A New Appraisal of Two Old Rivals. | Pishdad, R., et al. 2020. Am J Med Sci. 359: 212-217. PMID: 32200914
- Risk of hypoglycemia associated with repaglinide combined with clopidogrel, a retrospective cohort study. | Akagi, Y., et al. 2020. J Pharm Health Care Sci. 6: 5. PMID: 32206324
- Repaglinide and Metformin-Loaded Amberlite Resin-Based Floating Microspheres for the Effective Management of Type 2 Diabetes. | Jain, AK., et al. 2021. Curr Drug Deliv. 18: 654-668. PMID: 33106142
- Hypoglycemia during the Concomitant Use of Repaglinide and Clopidogrel in an Elderly Patient with Type 2 Diabetes and Severe Renal Insufficiency. | Takayama, K., et al. 2021. Intern Med. 60: 905-910. PMID: 33716254
- Antidiabetic and neuroprotective effects of a novel repaglinide analog. | Foroumadi, R., et al. 2022. J Biochem Mol Toxicol. 36: e23125. PMID: 35702883
- Repaglinide Elicits a Neuroprotective Effect in Rotenone-Induced Parkinson's Disease in Rats: Emphasis on Targeting the DREAM-ER Stress BiP/ATF6/CHOP Trajectory and Activation of Mitophagy. | Motawi, TK., et al. 2023. ACS Chem Neurosci. 14: 180-194. PMID: 36538285
Inhibitor of:
CYP2C8, GIP, Oatp2, Olr408, PTP IA-2β, and SUR1.Activator of:
IGRP, NMUR2, SUR-1, and SUR1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Repaglinide, 100 mg | sc-219959 | 100 mg | $215.00 | |||
Repaglinide, 250 mg | sc-219959A | 250 mg | $414.00 | |||
Repaglinide, 1 g | sc-219959B | 1 g | $1331.00 |