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Regadenoson (CAS 313348-27-5)

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Alternate Names:
2-[4-[(Methylamino)carbonyl]-1H-pyrazol-1-yl]adenosine
Application:
Regadenoson is a selective A2A adenosine receptor agonist in myocardial imaging
CAS Number:
313348-27-5
Purity:
≥98%
Molecular Weight:
390.35
Molecular Formula:
C15H18N8O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Regadenoson is a selective A2A adenosine receptor agonist that is extensively studied in the field of molecular pharmacology. It is particularly valuable for research on the cardiovascular system, where it is used to investigate the vasodilatory effects mediated by A2A receptor activation. This compound helps researchers understand the regulation of blood flow and the mechanisms leading to coronary vasodilation. In addition, regadenoson is utilized in studies that explore the cardioprotective effects of A2A receptor activation during episodes of ischemia or hypoxia. Moreover, regadenoson serves as a tool compound in the development of receptor-specific agonists and antagonists, contributing to the broader understanding of adenosine receptor pharmacology.


Regadenoson (CAS 313348-27-5) References

  1. Single bolus intravenous regadenoson injection versus central venous infusion of adenosine for maximum coronary hyperaemia in fractional flow reserve measurement.  |  van Nunen, LX., et al. 2015. EuroIntervention. 11: 905-13. PMID: 25136887
  2. The prognostic value of regadenoson myocardial perfusion imaging.  |  Hage, FG., et al. 2015. J Nucl Cardiol. 22: 1214-21. PMID: 25677160
  3. Regadenoson Stress Real-Time Myocardial Perfusion Echocardiography for Detection of Coronary Artery Disease: Feasibility and Accuracy of Two Different Ultrasound Contrast Agents.  |  Abdelmoneim, SS., et al. 2015. J Am Soc Echocardiogr. 28: 1393-400. PMID: 26416199
  4. ST Segment Elevation ECG Changes During Pharmacologic Stress With Regadenoson.  |  Qamruddin, S., et al. 2016. Clin Nucl Med. 41: 62-4. PMID: 26447370
  5. A useful and easy to develop combined stress test for myocardial perfusion imaging: Regadenoson and isometric exercise, preliminary results.  |  Janvier, L., et al. 2017. J Nucl Cardiol. 24: 34-40. PMID: 26542990
  6. AMPD1 polymorphism and response to regadenoson.  |  Saab, R., et al. 2015. Pharmacogenomics. 16: 1807-15. PMID: 26554440
  7. The effect of regadenoson-induced transient disruption of the blood-brain barrier on temozolomide delivery to normal rat brain.  |  Jackson, S., et al. 2016. J Neurooncol. 126: 433-9. PMID: 26626489
  8. Ventricular tachycardia during regadenoson SPECT myocardial perfusion imaging.  |  Andrikopoulou, E., et al. 2016. J Nucl Cardiol. 23: 1518-1520. PMID: 26626781
  9. Regadenoson stress for myocardial perfusion imaging.  |  Reyes, E. 2016. Future Cardiol. 12: 59-67. PMID: 26639775
  10. Safety and tolerability of regadenoson for myocardial perfusion imaging - first Danish experience.  |  Pape, M., et al. 2016. Scand Cardiovasc J. 50: 180-6. PMID: 26956081
  11. Aminophylline and caffeine for reversal of adverse symptoms associated with regadenoson SPECT MPI.  |  Doran, JA., et al. 2017. J Nucl Cardiol. 24: 1062-1070. PMID: 27025843
  12. Intravenous caffeine: An alternative to aminophylline to reverse adverse effects during regadenoson myocardial perfusion imaging.  |  Jolly, AF. and Thomas, GS. 2017. J Nucl Cardiol. 24: 1071-1074. PMID: 27071999
  13. The reproducibility and prognostic value of serial measurements of heart rate response to regadenoson during myocardial perfusion imaging.  |  Andrikopoulou, E., et al. 2016. Eur J Nucl Med Mol Imaging. 43: 1493-502. PMID: 27079736
  14. Regadenoson use in chronic kidney disease and end-stage renal disease: A focused review.  |  Vij, A., et al. 2018. J Nucl Cardiol. 25: 137-149. PMID: 28653271

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Regadenoson, 5 mg

sc-222245
5 mg
$260.00

What's uv peak and Landa max for regadenoson and what solvent use to measure it and what conctration

Asked by: Ali Mazen 1991
Thank you for your question. Unfortunately we do not test uv peak and Landa max, so we are unable to provide that information. Here is a link to a sample CoA for this product: http://datasheets.scbt.com/coa/coa.php?sc=sc-222245&lot=J1018
Answered by: Tech Service
Date published: 2019-10-28

What is the shipping temperature of this product?

Asked by: hawkeye11
This chemical, Regadenoson (CAS 313348-27-5), is shipped ambient.
Answered by: Chemical Support 1
Date published: 2019-01-25
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Rated 5 out of 5 by from FieldField, JJ. et al. (PubMed 23377438) reported that the adenosine A2A receptor agonist Regadenoson decreased activation of iNKT cells induced by sickle cell vaso-occlusion. -SCBT Publication Review
Date published: 2015-01-06
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Regadenoson is rated 5.0 out of 5 by 1.
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