RDHE2 Antibody (36-N): sc-100591
- RDHE2 Antibody (36-N) is a mouse monoclonal IgG2b κ RDHE2 antibody provided at 100 µg/ml
- raised against recombinant RDHE2 of human origin
- recommended for detection of RDHE2 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for RDHE2 Antibody (36-N). This work is in progress.
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RDHE2 Antibody (36-N) is a mouse monoclonal IgG2b kappa light chain antibody that detects RDHE2 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-RDHE2 antibody (36-N) is available as a non-conjugated monoclonal isotype antibody. RDHE2, also known as epidermal retinal dehydrogenase 2 or retSDR2, is a crucial enzyme in the short-chain dehydrogenase/reductase family, playing a vital role in converting retinol to retinaldehyde, an essential step in the visual cycle and retinol metabolism. RDHE2 is predominantly expressed in fetal and adult lung tissues, as well as in fetal kidney and skin, and is localized to the cell membrane as a multi-pass membrane protein. RDHE2′s structural integrity is characterized by three conserved motifs typical of the SDR family: a TGXXXGXG motif, a YXXXK motif that serves as the active site, and an LXNNAG motif, all critical for enzymatic function. RDHE2′s importance extends beyond metabolism; RDHE2 has been implicated in psoriasis vulgaris, a chronic inflammatory skin condition, as evidenced by significantly upregulated RDHE2 mRNA levels in affected skin of psoriasis patients, highlighting RDHE2′s potential as a biomarker for disease progression and therapeutic target.
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RDHE2 Antibody (36-N) References:
- Identification of the hRDH-E2 gene, a novel member of the SDR family, and its increased expression in psoriatic lesion. | Matsuzaka, Y., et al. 2002. Biochem Biophys Res Commun. 297: 1171-80. PMID: 12372410
- Expression pattern and biochemical characteristics of a major epidermal retinol dehydrogenase. | Markova, NG., et al. 2003. Mol Genet Metab. 78: 119-35. PMID: 12618084
- 17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells. | Chai, Z., et al. 2003. Endocrinology. 144: 2084-91. PMID: 12697717
- hRDH-E2 gene polymorphisms, variable transcriptional start sites, and psoriasis. | Matsuzaka, Y., et al. 2004. Mamm Genome. 15: 668-75. PMID: 15457346
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RDHE2 Antibody (36-N) | sc-100591 | 100 µg/ml | $316.00 |