Date published: 2025-9-23

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RC-160 (Vapreotide) (CAS 103222-11-3)

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Application:
RC-160 (Vapreotide) is an anticancer derivative of somatostatin
CAS Number:
103222-11-3
Molecular Weight:
1131.37
Molecular Formula:
C57H70N12O9S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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RC-160, also known as Vapreotide, has emerged as a valuable tool in scientific research due to its ability to selectively activate somatostatin receptors. This synthetic peptide derivative exhibits high affinity for somatostatin receptor subtype 2 (SST2), effectively modulating cellular signaling pathways associated with this receptor. Through its interaction with SST2, RC-160 regulates various physiological processes, including hormone secretion, neurotransmission, and cell proliferation. Research has utilized RC-160 to investigate the role of somatostatin signaling in neuroendocrine regulation, tumor growth inhibition, and immune modulation. Moreover, RC-160 has been instrumental in elucidating the molecular mechanisms underlying somatostatin receptor activation and downstream intracellular signaling cascades. Furthermore, the development of RC-160 analogs and derivatives has enabled researchers to optimize its pharmacological properties, enhance receptor selectivity, and explore its potential applications in targeted drug delivery and imaging techniques. Overall, RC-160 holds promise as a valuable research tool for unraveling the complexities of somatostatin signaling and its implications in various physiological and pathological conditions, offering insights into potential interventions and diagnostic approaches.


RC-160 (Vapreotide) (CAS 103222-11-3) References

  1. Phase II study of RC-160 (vapreotide), an octapeptide analogue of somatostatin, in the treatment of metastatic breast cancer.  |  O'Byrne, KJ., et al. 1999. Br J Cancer. 79: 1413-8. PMID: 10188884
  2. Response of patients with advanced prostatic cancer to administration of somatostatin analog RC-160 (vapreotide) at the time of relapse.  |  González-Barcena, D., et al. 2003. Prostate. 56: 183-91. PMID: 12772187
  3. Vapreotide: BMY 41606, RC 160, Sanvar.  |  . 2003. Drugs R D. 4: 326-30. PMID: 12952505
  4. Inhibition of growth of PC-82 human prostate cancer line xenografts in nude mice by bombesin antagonist RC-3095 or combination of agonist [D-Trp6]-luteinizing hormone-releasing hormone and somatostatin analog RC-160.  |  Milovanovic, SR., et al. 1992. Prostate. 20: 269-80. PMID: 1376910
  5. Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor.  |  Spitsin, S., et al. 2013. Neuroimmunomodulation. 20: 247-55. PMID: 23921645
  6. Neuroprotective Effects of Vapreotide on Tau Transfection-Induced Neurodegeneration.  |  Uzunhisarcıklı, E. and Yerer, MB. 2022. Neurotox Res. 40: 1824-1837. PMID: 36378411
  7. Effect of somatostatin analog RC-160 and bombesin/gastrin releasing peptide antagonist RC-3095 on growth of PC-3 human prostate-cancer xenografts in nude mice.  |  Pinski, J., et al. 1993. Int J Cancer. 55: 963-7. PMID: 7902829
  8. Effects of somatostatin analogue RC-160 and bombesin/gastrin-releasing peptide antagonists on the growth of human small-cell and non-small-cell lung carcinomas in nude mice.  |  Pinski, J., et al. 1994. Br J Cancer. 70: 886-92. PMID: 7947094
  9. Somatostatin analog RC-160 inhibits the growth of human osteosarcomas in nude mice.  |  Pinski, J., et al. 1996. Int J Cancer. 65: 870-4. PMID: 8631606

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

RC-160 (Vapreotide), 1 mg

sc-391147
1 mg
$131.00