RBM14 Antibody (4E1): sc-517183
- RBM14 Antibody (4E1) is a mouse monoclonal IgG2a κ RBM14 antibody provided at 100 µg/ml
- raised against amino acids 51-160 representing partial length RBM14 of human origin
- recommended for detection of RBM14 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for RBM14 Antibody (4E1). This work is in progress.
RBM14 Antibody (4E1) is a mouse monoclonal IgG2a kappa light chain antibody that detects RBM14 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-RBM14 antibody (4E1) is available as non-conjugated format. RBM14, also known as RNA-binding protein 14, SIP, CoAA, PSP2, SYTIP1, or TMEM137, is a 669 amino acid protein that plays a crucial role in the nucleus, where RBM14 is involved in gene expression regulation. RBM14 contains two RNA recognition motif (RRM) domains, which are essential for RNA binding and processing functions. RBM14 is expressed ubiquitously, with particularly high levels in heart, brain, liver, kidney, colon, lung, and skeletal muscle, and exists as two alternatively spliced isoforms exhibiting distinct cellular functions. The first isoform, CoAA, acts as a nuclear receptor coactivator, enhancing transcription through interactions with proteins such as MSG1 and PRIP. In contrast, the second isoform, CoAM, functions as a transcriptional repressor, modulating coactivator activities like CoAA. RBM14′s ability to regulate transcription is significant, as RBM14 may contribute to pathogenesis of various cancers, including kidney cell carcinoma, highlighting RBM14′s importance in both normal cellular processes and disease states.
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RBM14 Antibody (4E1) References:
- Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). | Iwasaki, T., et al. 2001. J Biol Chem. 276: 33375-83. PMID: 11443112
- Paraspeckles: a novel nuclear domain. | Fox, AH., et al. 2002. Curr Biol. 12: 13-25. PMID: 11790299
- The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins. | Perani, M., et al. 2005. J Biol Chem. 280: 42863-76. PMID: 16227627
- Gene amplification and associated loss of 5' regulatory sequences of CoAA in human cancers. | Sui, Y., et al. 2007. Oncogene. 26: 822-35. PMID: 16878147
- Switched alternative splicing of oncogene CoAA during embryonal carcinoma stem cell differentiation. | Yang, Z., et al. 2007. Nucleic Acids Res. 35: 1919-32. PMID: 17337438
- Dual roles for coactivator activator and its counterbalancing isoform coactivator modulator in human kidney cell tumorigenesis. | Kang, YK., et al. 2008. Cancer Res. 68: 7887-96. PMID: 18829545
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RBM14 Antibody (4E1) | sc-517183 | 100 µg/ml | $322.00 |