RBL-1 Whole Cell Lysate: sc-364790

RBL-1 whole cell lysate is derived from the RBL-1 cell line, a rat basophilic leukemia line that is extensively used in immunological and cellular signaling research. This lysate provides critical insights into the mechanisms of mast cell activation and the signaling processes involved in allergic responses. Researchers utilize RBL-1 lysate to study the biochemical pathways triggered by allergen exposure, focusing on the cascades such as the high-affinity IgE receptor (FcεRI) signaling pathway. This pathway plays a crucial role in degranulation and the release of histamine and other mediators critical in inflammatory responses. The lysate also facilitates investigations into the regulation of cytokine production, cellular degranulation, and the synthesis of lipid mediators like leukotrienes and prostaglandins. Furthermore, RBL-1 cell lysate is used to examine the effects of pharmacological agents on mast cell behavior, providing valuable data on the modulation of intracellular calcium levels and the activation of protein kinases involved in cell signaling. By studying these mechanisms, RBL-1 lysate contributes to a deeper understanding of immune cell dynamics and signaling, focusing strictly on cellular and molecular biology.