Molecular structure of Razoxane, CAS Number: 21416-67-1
Razoxane (CAS 21416-67-1)
Alternate Names:
(±)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane; (±)-1,2-Bis(3,5-dioxopiperazinyl)propane; 1,2-Bis(3,5-dioxo-1-piperazinyl)propane; 4,4′-Propylenebis(2,6-piperazinedione); ICI 59118; ICRF 159; NSC 129943; Razoxin; Tepirone; Troxozone
Application:
Razoxane is an inhibitor of Topo II
CAS Number:
21416-67-1
Molecular Weight:
268.27
Molecular Formula:
C11H16N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Razoxane is a compound that functions as a DNA intercalator and topoisomerase II inhibitor. It interacts with DNA by inserting itself between the base pairs, causing structural changes in the DNA molecule. This interaction interferes with the normal functioning of topoisomerase II, an enzyme involved in DNA replication and repair. By inhibiting this enzyme, razoxane disrupts the process of DNA unwinding and resealing, ultimately leading to DNA damage and cell death. Its mechanism of action at the molecular level involves the prevention of DNA strand break resealing, resulting in the accumulation of DNA breaks and ultimately leading to cell death. Razoxane ′s function in the development setting involves its role as a DNA intercalator and topoisomerase II inhibitor, contributing to the study of DNA damage and repair mechanisms.
Razoxane (CAS 21416-67-1) References
- A small prospective study of chordomas treated with radiotherapy and razoxane. | Rhomberg, W., et al. 2003. Strahlenther Onkol. 179: 249-53. PMID: 12707714
- Responses of liver metastases to radiotherapy and razoxane. | Hellmann, K., et al. 1992. J R Soc Med. 85: 136-8. PMID: 1556714
- Combined radiotherapy and razoxane in the treatment of chondrosarcomas and chordomas. | Rhomberg, W., et al. 2006. Anticancer Res. 26: 2407-11. PMID: 16821624
- Effects of rotational stress on the effectiveness of cyclophosphamide and razoxane in mice bearing Lewis lung carcinoma. | Perissin, L., et al. 1991. Clin Exp Metastasis. 9: 541-9. PMID: 1752084
- Therapeutic efficacy of two different cytostatic-linked phosphonates in combination with razoxane in the transplantable osteosarcoma of the rat. | Klenner, T., et al. 1990. Clin Exp Metastasis. 8: 345-59. PMID: 2350920
- Antimetastatic effects of razoxane in a rat osteosarcoma model. | Wingen, F., et al. 1987. Clin Exp Metastasis. 5: 9-16. PMID: 3470164
- Reduction of chronic doxorubicin cardiotoxicity in beagle dogs by bis-morpholinomethyl derivative of razoxane (ICRF-159). | Herman, EH., et al. 1987. Cancer Chemother Pharmacol. 19: 277-81. PMID: 3594714
- Phase I-II evaluation of razoxane (ICRF-159) and doxorubicin in gastrointestinal cancer. A Southeastern Cancer Study Group Trial. | DeSimone, PA., et al. 1986. Am J Clin Oncol. 9: 185-6. PMID: 3728369
- Razoxane in the treatment of psoriatic patients resistant to or intolerant of PUVA, methotrexate and etretinate. | Mom, A., et al. 1982. Acta Derm Venereol. 62: 357-8. PMID: 6183878
- The effects of razoxane (ICRF 159) on the production of collagenase and inhibitor (TIMP) by stimulated rabbit articular chondrocytes. | Duncan, SJ. and Reynolds, JJ. 1983. Biochem Pharmacol. 32: 3853-8. PMID: 6318774
- ICRF-159 (razoxane) in patients with advanced squamous cell carcinoma of the uterine cervix. For the Gynecologic Oncology Group. | Conroy, JF., et al. 1984. Am J Clin Oncol. 7: 131-3. PMID: 6702716
- Razoxane penetration into the cerebrospinal fluid of rats. | Greig, N., et al. 1982. Cancer Chemother Pharmacol. 8: 251-2. PMID: 7105386
- Interaction of razoxane and radiation on cultured Chinese hamster cells. | Kimler, BF. 1982. Int J Radiat Oncol Biol Phys. 8: 1333-8. PMID: 7141912
- Reduction of daunomycin toxicity by razoxane. | Wang, G., et al. 1981. Br J Cancer. 43: 871-7. PMID: 7248163
- Cell cycle progression and chromosome segregation in mammalian cells cultured in the presence of the topoisomerase II inhibitors ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane; ADR-529] and ICRF-159 (Razoxane). | Gorbsky, GJ. 1994. Cancer Res. 54: 1042-8. PMID: 8313360
Inhibitor of:
Apoptosis, and Topo II.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Razoxane, 5 mg | sc-253425 | 5 mg | $73.00 | |||
Razoxane, 25 mg | sc-253425A | 25 mg | $294.00 |