RAW 264.7 + UV Cell Lysate: sc-24769

RAW 264.7 + UV cell lysate is derived from the RAW 264.7 murine macrophage cell line exposed to ultraviolet (UV) radiation, a tool commonly used to study cellular stress responses and the immune system's reaction to DNA damage. Researchers utilize this lysate to investigate how UV exposure affects macrophage function, particularly focusing on the activation of DNA damage response (DDR) pathways and their role in modulating immune responses. The lysate enables the study of the activation of stress response proteins such as p53, a key regulator of the cell cycle and apoptosis in response to DNA damage. It also facilitates analysis of the production and release of cytokines that occur as part of the inflammatory response to cellular stress. Additionally, RAW 264.7 + UV cell lysate is instrumental in examining the expression of repair enzymes that are upregulated in response to UV-induced DNA lesions. By using this lysate, scientists can explore the complex interplay between cellular stress mechanisms and immune signaling, providing insights into how macrophages maintain cellular integrity and function under stress conditions.