Molecular structure of Rauwolscine • HCl, CAS Number: 6211-32-1
Rauwolscine • HCl (CAS 6211-32-1)
Alternate Names:
α-Yohimbine hydrochloride
Application:
Rauwolscine • HCl is a standard α-2-adrenergic (AR) antagonist
CAS Number:
6211-32-1
Purity:
≥98%
Molecular Weight:
390.9
Molecular Formula:
C21H26N2O3•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Rauwolscine • HCl is a standard alpha2-adrenergic antagonist (Ki values are 3.5, 4.6, and 0.6 nM at cloned human alpha2A-AR,, alpha2B-AR, and alpha2C-AR adrenoceptors respectively). Also exhibits partial agonist characteristics at SR-1A (5-HT1A receptors). Rauwolscine hydrochloride acts as an agonist at α2-adrenergic receptors, resulting in increased norepinephrine release. It also acts as an antagonist at α1-adrenergic receptors, resulting in decreased norepinephrine release. In addition, it may act to inhibit the reuptake of serotonin, dopamine, and noradrenaline, and to act as an inhibitor of monoamine oxidase.
Rauwolscine • HCl (CAS 6211-32-1) References
- Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. | Hieble, JP., et al. 1995. J Med Chem. 38: 3415-44. PMID: 7658428
- Dopaminergic and alpha-adrenergic control of neurotransmission in human right atrium. | Rump, LC., et al. 1995. J Cardiovasc Pharmacol. 26: 462-70. PMID: 8583789
Inhibitor of:
alpha2A-AR, alpha2B-AR, alpha2C-AR, MrgB5, MTH1, Olfr1023, Olfr341, Olfr881, SC, TCP-1 ε, TRH-DE, and XBP-1.Activator of:
SR-1A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rauwolscine • HCl, 100 mg | sc-200151 | 100 mg | $105.00 |