Ratjadone C (native)
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Ratjadone C (native) is a member of a new class of natural compounds that inhibit proliferation in eukaryotes through nuclear export blocking. Ratjadone C is isolated from a strain of myxobacterium Sorangium cellulosum, the same strain from which Ratjadone B and D are isolated.It is a cytotoxic secondary metabolite that inhibits cell growth of mammalian cell lines including multidrug resistant (MDR) HeLa cells. Ratjadone C (native) is similar to leptomycin B, ratjadone C binds covalently to the nuclear export protein CRM1. It inhibits cargo protein binding to the leucine-rich nuclear export sequence and thereby blocks nuclear export. Exhibits antibiotic activity against yeast and filamentous fungi.
Ratjadone C (native) References
- Ratjadones inhibit nuclear export by blocking CRM1/exportin 1. | Köster, M., et al. 2003. Exp Cell Res. 286: 321-31. PMID: 12749860
- Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway. | Tinel, A., et al. 2007. EMBO J. 26: 197-208. PMID: 17159900
- The second AT-hook of the architectural transcription factor HMGA2 is determinant for nuclear localization and function. | Cattaruzzi, G., et al. 2007. Nucleic Acids Res. 35: 1751-60. PMID: 17324944
- PP2A regulates HDAC4 nuclear import. | Paroni, G., et al. 2008. Mol Biol Cell. 19: 655-67. PMID: 18045992
- Human multiple myeloma cells are sensitized to topoisomerase II inhibitors by CRM1 inhibition. | Turner, JG., et al. 2009. Cancer Res. 69: 6899-905. PMID: 19690141
- Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia. | Lapalombella, R., et al. 2012. Blood. 120: 4621-34. PMID: 23034282
- CRM1 Inhibition Sensitizes Drug Resistant Human Myeloma Cells to Topoisomerase II and Proteasome Inhibitors both In Vitro and Ex Vivo. | Turner, JG., et al. 2013. J Cancer. 4: 614-25. PMID: 24155773
- Selective inhibitors of nuclear export (SINE) in hematological malignancies. | Das, A., et al. 2015. Exp Hematol Oncol. 4: 7. PMID: 25745591
- Ratjadone C-mediated nuclear accumulation of HDAC4: implications on Runx2-induced osteoblast differentiation of C3H10T1/2 mesenchymal stem cells. | Mu, P., et al. 2014. Z Naturforsch C J Biosci. 69: 471-8. PMID: 25854767
- Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. | Wolff, B., et al. 1997. Chem Biol. 4: 139-47. PMID: 9190288
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ratjadone C (native), 5 µg | sc-204876 | 5 µg | $207.00 |