RASSF8 Antibody (4B1): sc-81934

RASSF8 Antibody (4B1) is a mouse monoclonal IgG2a kappa light chain antibody that detects RASSF8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-RASSF8 antibody (4B1) is available as the non-conjugated format. RASSF8, also known as HoJ-1, is a member of the Ras association (RalGDS/AF-6 or RA) domain family and plays a crucial role in the Ras signaling pathway, which is vital for regulating cell growth and differentiation. RASSF8 is primarily located in the cytoplasm and has been shown to translocate to the nucleus under certain conditions, highlighting a potential role in cellular signaling and tumor suppression. RASSF8 has been implicated in lung cancer, where ectopic expression can inhibit anchorage-independent growth, suggesting that loss of functional RASSF8 may contribute to tumorigenesis. Additionally, a reciprocal chromosomal translocation involving RASSF8 and Fibulin-1 has been associated with synpolydactyly, a condition characterized by the presence of extra digits and webbing of fingers and toes, further emphasizing RASSF8′s importance in developmental processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

RASSF8 Antibody (4B1) References:

1. The fibulin-1 gene (FBLN1) is disrupted in a t(12;22) associated with a complex type of synpolydactyly.  |  Debeer, P., et al. 2002. J Med Genet. 39: 98-104. PMID: 11836357
2. Identification of RASSF8 as a candidate lung tumor suppressor gene.  |  Falvella, FS., et al. 2006. Oncogene. 25: 3934-8. PMID: 16462760
3. Common polymorphisms in D12S1034 flanking genes RASSF8 and BHLHB3 are not associated with lung adenocarcinoma risk.  |  Falvella, FS., et al. 2007. Lung Cancer. 56: 1-7. PMID: 17194498
4. RASSF7 is a member of a new family of RAS association domain-containing proteins and is required for completing mitosis.  |  Sherwood, V., et al. 2008. Mol Biol Cell. 19: 1772-82. PMID: 18272789

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RASSF8 Antibody (4B1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-RASSF8 Antibody (4B1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RASSF8 Antibody (4B1) Specifications

Alternate Product Name: RASSF8

Product Clone Name: 4B1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 40-138

Epitope Target: RASSF8

Epitope Species: human

Product Reactivity/Detection: RASSF8

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for RASSF8 Antibody (4B1): N/A