Date published: 2026-4-25

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RAPGEFL1 Antibody (R-93): sc-81908

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  • RAPGEFL1 Antibody (R-93) is a mouse monoclonal IgG2a κ RAPGEFL1 antibody provided at 50 µg/0.5 ml
  • raised against recombinant RAPGEFL1 of human origin
  • recommended for detection of RAPGEFL1 of mouse, rat and human origin by WB, IP and ELISA
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for RAPGEFL1 Antibody (R-93). This work is in progress.
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    RAPGEFL1 Antibody (R-93) is a mouse monoclonal IgG2a kappa light chain antibody that detects RAPGEFL1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-RAPGEFL1 antibody (R-93) is available as a non-conjugated format. RAPGEFL1 protein, also known as Link-GEFII, is a 456 amino acid guanine nucleotide exchange factor that plays a crucial role in activating various Rap proteins, which are part of the Ras superfamily of GTPases. These GTPases are essential for regulating multiple cellular functions, including cytoskeletal dynamics, nuclear signaling, and cell proliferation. RAPGEFL1 involvement in growth-factor signaling pathways is critical for processes such as cell differentiation and neurite outgrowth. By facilitating the exchange of GDP for GTP on Rap proteins, RAPGEFL1 acts as a molecular switch that can influence cellular responses to external stimuli, thereby impacting developmental and physiological processes. RAPGEFL1′s ability to modulate these pathways underscores its significance in both normal cellular function and potential pathological conditions, making RAPGEFL1 a valuable target for research in cell biology and therapeutic development.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

    Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

    LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

    RAPGEFL1 Antibody (R-93) References:

    1. SmartCapture and the frontiers of FISH technology: report of the Digital Scientific UK SmartCapture User's Meeting, Peterhouse College Cambridge, UK, 2nd September 2005.  |  Reid, AG. and Gribble, SM. 2005. Chromosome Res. 13: 835-8. PMID: 16331415
    2. Ultra-high resolution array painting facilitates breakpoint sequencing.  |  Gribble, SM., et al. 2007. J Med Genet. 44: 51-8. PMID: 16971479
    3. Genomic and nongenomic effects of estrogen signaling in human endometrial cells: involvement of the growth factor receptor signaling downstream AKT pathway.  |  Gielen, SC., et al. 2007. Reprod Sci. 14: 646-54. PMID: 18000226
    4. Estimation of the fraction of cancer cells in a tumor DNA sample using DNA methylation.  |  Takahashi, T., et al. 2013. PLoS One. 8: e82302. PMID: 24312652
    5. Screening aberrant methylation profile in esophageal squamous cell carcinoma for Kazakhs in Xinjiang area of China.  |  Chen, Y., et al. 2015. Mol Biol Rep. 42: 457-64. PMID: 25304811
    6. RASA3 is a critical inhibitor of RAP1-dependent platelet activation.  |  Stefanini, L., et al. 2015. J Clin Invest. 125: 1419-32. PMID: 25705885
    7. Screening pathogenic genes in oral squamous cell carcinoma based on the mRNA expression microarray data.  |  Ding, Y., et al. 2018. Int J Mol Med. 41: 3597-3603. PMID: 29512771
    8. Difference of molecular alterations in HER2-positive and HER2-negative gastric cancers by whole-genome sequencing analysis.  |  Zhou, C., et al. 2018. Cancer Manag Res. 10: 3945-3954. PMID: 30310315
    9. Targeting FGFR in non-small cell lung cancer: implications from the landscape of clinically actionable aberrations of FGFR kinases.  |  Zhou, Z., et al. 2021. Cancer Biol Med. 18: 490-501. PMID: 33710807
    10. Establishment of a Macrophage Phenotypic Switch Related Prognostic Signature in Patients With Pancreatic Cancer.  |  Li, MX., et al. 2021. Front Oncol. 11: 619517. PMID: 33747931
    11. RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs.  |  Ebinu, JO., et al. 1998. Science. 280: 1082-6. PMID: 9582122
    12. A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia.  |  Kawasaki, H., et al. 1998. Proc Natl Acad Sci U S A. 95: 13278-83. PMID: 9789079

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    RAPGEFL1 Antibody (R-93)

    sc-81908
    50 µg/0.5 ml
    $322.00

    For Western Blot, is it recommended to use denatured or non-denatured conditions with RAPGEFL1 (R-93): sc-81908 antibody?

    Asked by: jerojero
    Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
    Answered by: Technical Support
    Date published: 2017-03-27
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    Rated 5 out of 5 by from Good for Western BlotThis antibody detects a band at the expected molecular weight in IMR-32. Non-specific bands may be present. -SCBT QC
    Date published: 2023-09-14
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    RAPGEFL1 Antibody (R-93) is rated 5.0 out of 5 by 2.
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