RANTES Antibody (C-12): sc-373984
- RANTES Antibody (C-12) is a mouse monoclonal IgG3 κ, cited in 5 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 65-91 at the C-terminus of RANTES of human origin
- recommended for detection of RANTES of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG3 BP-HRP is the preferred secondary detection reagent for RANTES Antibody (C-12) for WB applications. This reagent is now offered in a bundle with RANTES Antibody (C-12) (see ordering information below).
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RANTES Antibody (C-12) is a mouse monoclonal IgG3 antibody that detects RANTES in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RANTES, also known as regulated upon activation, normal T cell expressed and secreted, plays a crucial role in the immune response by acting as a potent chemoattractant for various immune cells, including monocytes and natural killer cells. RANTES is primarily expressed by platelets, eosinophils, fibroblasts, macrophages, endothelial cells, and T lymphocytes, highlighting RANTES′s importance in mediating inflammatory responses and recruiting immune cells to sites of infection or injury. Notably, RANTES is characterized by a unique structure that includes a set of conserved cysteine residues, which are essential for stability and function. The presence of these cysteines allows for the formation of disulfide bonds, contributing to RANTES′s three-dimensional conformation and ability to interact with specific receptors on target cells. Understanding the structural features of RANTES is vital, as these features directly influence biological activity and the subsequent immune response, making anti-RANTES antibody (C-12) an invaluable tool for researchers studying immune mechanisms and inflammatory diseases.
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RANTES Antibody (C-12) References:
- RANTES production by cultured primate endometrial epithelial cells. | Altman, GB., et al. 1999. Am J Reprod Immunol. 42: 168-74. PMID: 10517177
- RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium. | von Hundelshausen, P., et al. 2001. Circulation. 103: 1772-7. PMID: 11282909
- Chemokine RANTES in severe pulmonary arterial hypertension. | Dorfmüller, P., et al. 2002. Am J Respir Crit Care Med. 165: 534-9. PMID: 11850348
- RANTES: a genetic risk marker for multiple sclerosis. | Gade-Andavolu, R., et al. 2004. Mult Scler. 10: 536-9. PMID: 15471370
- Exhaled RANTES and interleukin 4 levels after exercise challenge in children with asthma. | Keskin, O., et al. 2012. Ann Allergy Asthma Immunol. 109: 303-8. PMID: 23062383
- Stability of 5P12-RANTES, A Candidate Rectal Microbicide, in Human Rectal Lavage. | Cerini, F., et al. 2017. AIDS Res Hum Retroviruses. 33: 768-777. PMID: 28177261
- Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma. | Li, N., et al. 2021. iScience. 24: 103163. PMID: 34693221
- RANTES chemokine expression in cell-mediated transplant rejection of the kidney. | Pattison, J., et al. 1994. Lancet. 343: 209-11. PMID: 7507196
- RANTES and MCP-3 antagonists bind multiple chemokine receptors. | Gong, JH., et al. 1996. J Biol Chem. 271: 10521-7. PMID: 8631850
- CD26-processed RANTES(3-68), but not intact RANTES, has potent anti-HIV-1 activity. | Schols, D., et al. 1998. Antiviral Res. 39: 175-87. PMID: 9833958
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RANTES Antibody (C-12) | sc-373984 | 200 µg/ml | $322.00 | |||
RANTES Antibody (C-12): m-IgG3 BP-HRP Bundle | sc-550444 | 200 µg Ab; 40 µg BP | $361.00 | |||
RANTES (C-12) Neutralizing Peptide | sc-373984 P | 100 µg/0.5 ml | $69.00 |