Date published: 2025-9-17

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Ranitidine hydrochloride (CAS 66357-59-3)

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Application:
Ranitidine hydrochloride is a histamine H2-receptor antagonist
CAS Number:
66357-59-3
Purity:
≥95%
Molecular Weight:
350.86
Molecular Formula:
C13H22N4O3S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ranitidine hydrochloride is a histamine H2-receptor antagonist that functions by competitively inhibiting the action of histamine at the H2 receptors of the parietal cells in the stomach. This inhibition results in a reduction in the volume of gastric secretions, as well as a decrease in the overall concentration of hydrogen ions. By decreasing the production of gastric acid, ranitidine hydrochloride can help to create a less acidic environment. Ranitidine hydrochloride′s mode of action involves binding to the H2 receptors on the basolateral membrane of the parietal cell, which ultimately leads to a decrease in the production of gastric acid. Ranitidine hydrochloride may have a cytoprotective effect on the gastric mucosa, which may contribute to its overall impact on reducing gastric acid secretion. Ranitidine hydrochloride plays a role in modulating the production of gastric acid in experimental applications.


Ranitidine hydrochloride (CAS 66357-59-3) References

  1. Ranitidine hydrochloride X-ray assay using a neural network.  |  Agatonovic-Kustrin, S., et al. 2000. J Pharm Biomed Anal. 22: 985-92. PMID: 10857567
  2. Ranitidine hydrochloride, a polymorphic crystal form.  |  Hempel, A., et al. 2000. Acta Crystallogr C. 56 (Pt 8): 1048-9. PMID: 10944325
  3. Bioadhesive ranitidine hydrochloride for gastroretention with controlled microenvironmental pH.  |  Adhikary, A. and Vavia, PR. 2008. Drug Dev Ind Pharm. 34: 860-9. PMID: 18618306
  4. Quantification of ranitidine hydrochloride in the presence of its decomposition product by spectrophotometric methods. Application for kinetic study.  |  Sokół, A., et al. 2011. Acta Pol Pharm. 68: 169-77. PMID: 21485289
  5. Ranitidine Hydrochloride-loaded Ethyl Cellulose and Eudragit RS 100 Buoyant Microspheres: Effect of pH Modifiers.  |  Kotagale, NR., et al. 2011. Indian J Pharm Sci. 73: 626-33. PMID: 23112396
  6. Stability of Ranitidine Hydrochloride with Cefazolin Sodium, Cefbuperazone Sodium, Cefoxitin Sodium and Cephalothin Sodium during Simulated Y-Site Administration.  |  Inagaki, K., et al. 2000. Int J Pharm Compd. 4: 150-3. PMID: 23985950
  7. Chromatographic methods for determining the identity, strength and purity of ranitidine hydrochloride both in the drug substance and its dosage forms--an exercise in method selection, development, definition and validation.  |  Evans, MB., et al. 1989. J Pharm Biomed Anal. 7: 1-22. PMID: 2488600
  8. Discrimination of ranitidine hydrochloride crystals using X-ray micro-computed tomography for the evaluation of three-dimensional spatial distribution in solid dosage forms.  |  Yamamoto, E., et al. 2021. Int J Pharm. 605: 120834. PMID: 34192587
  9. N-Nitrosodimethylamine (NDMA) Formation from Ranitidine Impurities: Possible Root Causes of the Presence of NDMA in Ranitidine Hydrochloride.  |  Yokoo, H., et al. 2021. Chem Pharm Bull (Tokyo). 69: 872-876. PMID: 34470951
  10. Ultrasensitive Functionalized Polymeric-Nanometal Oxide Sensors for Potentiometric Determination of Ranitidine Hydrochloride.  |  Alshehri, EM., et al. 2022. Polymers (Basel). 14: PMID: 36236096
  11. Ranitidine hydrochloride-induced hypergastrinemia.  |  Chisholm, JC. 1985. J Natl Med Assoc. 77: 303-4. PMID: 3999148
  12. Stability of paclitaxel with ondansetron hydrochloride or ranitidine hydrochloride during simulated Y-site administration.  |  Burm, JP., et al. 1994. Am J Hosp Pharm. 51: 1201-4. PMID: 7913797
  13. The safety of ranitidine in over a decade of use.  |  Mills, JG., et al. 1997. Aliment Pharmacol Ther. 11: 129-37. PMID: 9042985

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ranitidine hydrochloride, 1 g

sc-204874
1 g
$33.00