Date published: 2026-4-28

1-800-457-3801

SCBT Portrait Logo
Seach Input

Ramosetron Hydrochloride (CAS 132907-72-3)

0.0(0)
Write a reviewAsk a question

Alternate Names:
(1-Methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benzimidazol-6-yl]methanone Hydrochloride
CAS Number:
132907-72-3
Molecular Weight:
315.80
Molecular Formula:
C17H18ClN3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Ramosetron hydrochloride is a serotonin 5-HT3 receptor antagonist that functions by selectively blocking the action of serotonin at 5-HT3 receptors. Ramosetron Hydrochloride′s mechanism of action involves inhibiting the binding of serotonin to these receptors, which are located on nerve cells in the gut and central nervous system. By doing so, it interferes with the transmission of signals that can lead to nausea and vomiting. At the molecular level, ramosetron hydrochloride binds to the 5-HT3 receptors, preventing the activation of these receptors by serotonin. This interference with the serotonin signaling pathway ultimately reduces the likelihood of nausea and vomiting. In development setting, Ramosetron Hydrochloride functions as a serotonin 5-HT3 receptor antagonist is of interest for investigating the role of serotonin in the regulation of gut and central nervous system function. Its mechanism of action provides insight into the molecular mechanisms underlying nausea and vomiting, contributing to a better understanding of these physiological processes.


Ramosetron Hydrochloride (CAS 132907-72-3) References

  1. [Usefulness of ramosetron hydrochloride on nausea and vomiting in CMF or CEF therapy for breast cancer].  |  Taguchi, T., et al. 1999. Gan To Kagaku Ryoho. 26: 1163-70. PMID: 10431583
  2. Mucoadhesive suppositories of ramosetron hydrochloride utilizing Carbopol.  |  Yahagi, R., et al. 2000. Int J Pharm. 193: 205-12. PMID: 10606783
  3. [Pharmacological and clinical profile of ramosetron hydrochloride (Irribow), a novel therapeutic agent for irritable bowel syndrome with diarrhea].  |  Hirata, T., et al. 2009. Nihon Yakurigaku Zasshi. 133: 281-91. PMID: 19443966
  4. Ramosetron hydrochloride for the prevention of cancer chemotherapy induced nausea and vomiting: The Indian experience.  |  Sanmukhani, JJ., et al. 2014. South Asian J Cancer. 3: 132-7. PMID: 24818110
  5. Japanese Practice Guidelines for Fecal Incontinence Part 2-Examination and Conservative Treatment for Fecal Incontinence- English Version.  |  Maeda, K., et al. 2021. J Anus Rectum Colon. 5: 67-83. PMID: 33537502
  6. Sex-Gender Differences in the Effectiveness of Treatment of Irritable Bowel Syndrome: A Systematic Review.  |  van Kessel, L., et al. 2021. Int J Gen Med. 14: 867-884. PMID: 33758534
  7. Persistent diarrhea following catheter ablation for atrial fibrillation: A lesser-known complication of left atrial ablation procedures.  |  Yamane, T., et al. 2021. HeartRhythm Case Rep. 7: 633-636. PMID: 34552858
  8. A patient with familial Mediterranean fever mimicking diarrhea-dominant irritable bowel syndrome who successfully responded to treatment with colchicine: a case report.  |  Kumei, S., et al. 2022. J Med Case Rep. 16: 247. PMID: 35739566
  9. Signet-ring cell carcinoma of the appendix with ganglioneuromatosis: a case report.  |  Sato, A., et al. 2022. Surg Case Rep. 8: 151. PMID: 35927360
  10. Physical compatibility and chemical stability of dezocine and ramosetron in 0.9% sodium chloride injection for patient-controlled analgesia administration.  |  Guo, Z. and Chen, P. 2022. Medicine (Baltimore). 101: e31546. PMID: 36397408
  11. Differential diagnosis of ulcerative colitis with increased diarrhea; collagenous colitis or irritable bowel syndrome? A case report.  |  Haraikawa, M., et al. 2022. J Int Med Res. 50: 3000605221140686. PMID: 36474409
  12. Effect of anesthetics on postoperative nausea and vomiting after peripheral vascular surgery in end-stage renal disease patients: A retrospective observational study.  |  Cho, HB., et al. 2022. Front Surg. 9: 1054670. PMID: 36504578
  13. [A new antiemetic ramosetron hydrochloride].  |  Tsukagoshi, S. 1997. Gan To Kagaku Ryoho. 24: 371-80. PMID: 9051143

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ramosetron Hydrochloride, 10 mg

sc-477143
10 mg
$360.00