Molecular structure of Ramiprilat Diketopiperazine, CAS Number: 108736-10-3
Ramiprilat Diketopiperazine (CAS 108736-10-3)
Application:
Ramiprilat Diketopiperazine is an active metabolite of Ramipril
CAS Number:
108736-10-3
Molecular Weight:
370.44
Molecular Formula:
C21H26N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ramiprilat Diketopiperazine is a metabolite of Ramiprilat (sc-212767). Ramiprilat is the active metabolite of Ramipril (sc-205833). Ramipril is an inhibitor of the angiotensin- converting enzyme (ACE) that is reported to quickly hydrolyze into Ramiprilat. Studies indicate that Ramipril is a more potent inhibitor in comparison to Zofenopril (sc-208496). Acute coronary syndrome investigations demonstrate that Ramipril increases IL-10, and decreases the levels of MCP-1 and IL-18. Ramiprilat has been reported to bind to ACE on the surface of endothelial cells and activate cell-specific signaling, which includes induction of the activator protein (AP)-1.
Ramiprilat Diketopiperazine (CAS 108736-10-3) References
- Spotlight on ramipril in the prevention of cardiovascular outcomes. | Warner, GT. and Perry, CM. 2003. Am J Cardiovasc Drugs. 3: 113-6. PMID: 14727938
- Direct effects of the angiotensin-converting enzyme inhibitor ramiprilat on adult rat ventricular cardiomyocytes. | Helmig, S., et al. 2007. Acta Physiol (Oxf). 191: 267-74. PMID: 17825088
- Pharmacokinetics and pharmacodynamics of ramipril and ramiprilat in healthy cats. | Desmoulins, PO., et al. 2008. J Vet Pharmacol Ther. 31: 349-58. PMID: 18638296
- Bioanalytical method development and validation using incurred samples--simultaneous quantitation of ramipril and ramiprilat in human EDTA plasma by LC-MS/MS. | Tan, A., et al. 2009. J Chromatogr B Analyt Technol Biomed Life Sci. 877: 3673-80. PMID: 19782651
- [Pulmonary thromboembolism during cyclosporin immunosuppressive treatment in a heart transplant patient]. | Martí, V., et al. 1991. Med Clin (Barc). 96: 197. PMID: 2033996
- Differences between zofenopril and ramipril, two ACE inhibitors, on cough induced by citric acid in guinea pigs: role of bradykinin and PGE2. | Cialdai, C., et al. 2010. Naunyn Schmiedebergs Arch Pharmacol. 382: 455-61. PMID: 20848272
- Impact of methylation of acyl glucuronide metabolites on incurred sample reanalysis evaluation: ramiprilat case study. | Côté, C., et al. 2011. Bioanalysis. 3: 951-65. PMID: 21545343
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ramiprilat Diketopiperazine, 1 mg | sc-212768 | 1 mg | $430.00 |