Molecular structure of Ramiprilat, CAS Number: 87269-97-4
Ramiprilat (CAS 87269-97-4)
See product citations (5)
Alternate Names:
Ramiprilat is also known as Ramipril Diacid.
Application:
Ramiprilat is the active metabolite of Ramipril that functions as an inhibits angiotensin-converting enzymes.
CAS Number:
87269-97-4
Purity:
≥97%
Molecular Weight:
388.46
Molecular Formula:
C21H28N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ramiprilat is the active metabolite of Ramipril (sc-205833). Ramipril is an inhibitor of the angiotensin- coverting enzyme (ACE) that is reported to quickly hydrolyze into Ramiprilat, after absorption. Studies indicate that Ramipril is a more potent inhibitor in comparison to Zofenopril (sc-208496). Acute coronary syndrome investigations demonstrate that Ramipril increases IL-10, and decreases the levels of MCP-1 and IL-18. Ramiprilat has been reported to bind to ACE on the surface of endothelial cells and activate cell-specific signaling, which includes induction of the activator protein (AP)-1. Bradykinin signaling is prevented by Ramiprilat after it interferes with the targeting of B2 kinin receptors to endothelial cell membranes.
Ramiprilat (CAS 87269-97-4) References
- Spotlight on ramipril in the prevention of cardiovascular outcomes. | Warner, GT. and Perry, CM. 2003. Am J Cardiovasc Drugs. 3: 113-6. PMID: 14727938
- Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat. | Levitt, DG. and Schoemaker, RC. 2006. BMC Clin Pharmacol. 6: 1. PMID: 16398929
- Direct effects of the angiotensin-converting enzyme inhibitor ramiprilat on adult rat ventricular cardiomyocytes. | Helmig, S., et al. 2007. Acta Physiol (Oxf). 191: 267-74. PMID: 17825088
- Pharmacokinetics and pharmacodynamics of ramipril and ramiprilat in healthy cats. | Desmoulins, PO., et al. 2008. J Vet Pharmacol Ther. 31: 349-58. PMID: 18638296
- [Pulmonary thromboembolism during cyclosporin immunosuppressive treatment in a heart transplant patient]. | Martí, V., et al. 1991. Med Clin (Barc). 96: 197. PMID: 2033996
- Differences between zofenopril and ramipril, two ACE inhibitors, on cough induced by citric acid in guinea pigs: role of bradykinin and PGE2. | Cialdai, C., et al. 2010. Naunyn Schmiedebergs Arch Pharmacol. 382: 455-61. PMID: 20848272
- Simultaneous determination of ramipril, ramiprilat and telmisartan in human plasma using liquid chromatography tandem mass spectrometry. | Gupta, VK., et al. 2011. Talanta. 83: 709-16. PMID: 21147310
- Influence of ramiprilat and losartan on ischemia reperfusion injury in rat hearts. | Safari, F., et al. 2012. J Renin Angiotensin Aldosterone Syst. 13: 29-35. PMID: 22076778
- In vitro interactions between ramiprilat and angiotensin I-converting enzyme in endothelial cells. | Baudin, B. and Drouet, L. 1989. J Cardiovasc Pharmacol. 14 Suppl 4: S37-42. PMID: 2483427
- Pharmacokinetics and pharmacodynamics of ramipril and ramiprilat after intravenous and oral doses of ramipril in healthy horses. | Serrano-Rodríguez, JM., et al. 2016. Vet J. 208: 38-43. PMID: 26639833
- Ramiprilat attenuates the local release of noradrenaline in the ischemic myocardium. | Carlsson, L. and Abrahamsson, T. 1989. Eur J Pharmacol. 166: 157-64. PMID: 2792189
- Lack of Male-Female Differences in Disposition and Esterase Hydrolysis of Ramipril to Ramiprilat in Healthy Volunteers after a Single Oral Dose. | Vree, TB., et al. 2003. ScientificWorldJournal. 3: 1344-1358. PMID: 29887764
- Central nervous and systemic kinetics of ramipril and ramiprilat in the conscious dog. | Nordström, M., et al. 1993. J Pharmacol Exp Ther. 266: 147-52. PMID: 8331554
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ramiprilat, 1 mg | sc-212767A | 1 mg | $142.00 | |||
Ramiprilat, 2 mg | sc-212767B | 2 mg | $214.00 | |||
Ramiprilat, 5 mg | sc-212767C | 5 mg | $339.00 | |||
Ramiprilat, 10 mg | sc-212767 | 10 mg | $526.00 | |||
Ramiprilat, 25 mg | sc-212767D | 25 mg | $942.00 |