Raloxifene 4′-Glucuronide (CAS 182507-22-8)
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Raloxifene 4′-glucuronide, a metabolite of raloxifene, is extensively studied in the context of chemical metabolism, providing insights into the glucuronidation process, an essential phase II reaction of substance biotransformation. This compound is pivotal for understanding the metabolism of raloxifene as it undergoes conjugation with glucuronic acid, which is catalyzed by the uridine 5′-diphospho-glucuronosyltransferase (UGT) enzymes in the liver, leading to increased aqueous solubility and facilitating renal and biliary excretion. Serving as a key analytical standard, raloxifene 4′-glucuronide enables researchers to develop and validate precise bioanalytical methods for measuring the parent compound and its metabolites in bodily fluids, which is for determining the compound′s disposition and elimination patterns.
Raloxifene 4′-Glucuronide (CAS 182507-22-8) References
- Pharmacokinetics of raloxifene in male Wistar-Hannover rats: influence of complexation with hydroxybutenyl-beta-cyclodextrin. | Wempe, MF., et al. 2008. Int J Pharm. 346: 25-37. PMID: 17644287
- Metabolic inhibition and kinetics of raloxifene by pharmaceutical excipients in human liver microsomes. | Kim, AR., et al. 2009. Int J Pharm. 368: 37-44. PMID: 18977285
- Effects of UGT1A1*28 polymorphism on raloxifene pharmacokinetics and pharmacodynamics. | Trontelj, J., et al. 2009. Br J Clin Pharmacol. 67: 437-44. PMID: 19371317
- The role of pH in the glucuronidation of raloxifene, mycophenolic acid and ezetimibe. | Chang, JH., et al. 2009. Mol Pharm. 6: 1216-27. PMID: 19449843
- In vitro metabolism, permeability, and efflux of bazedoxifene in humans. | Shen, L., et al. 2010. Drug Metab Dispos. 38: 1471-9. PMID: 20516255
- Effect of UDP-glucuronosyltransferase 1A8 polymorphism on raloxifene glucuronidation. | Kokawa, Y., et al. 2013. Eur J Pharm Sci. 49: 199-205. PMID: 23499758
- Characterization of raloxifene glucuronidation: potential role of UGT1A8 genotype on raloxifene metabolism in vivo. | Sun, D., et al. 2013. Cancer Prev Res (Phila). 6: 719-30. PMID: 23682072
- Bone cell-independent benefits of raloxifene on the skeleton: a novel mechanism for improving bone material properties. | Gallant, MA., et al. 2014. Bone. 61: 191-200. PMID: 24468719
- Raloxifene inhibits cloned Kv4.3 channels in an estrogen receptor-independent manner. | Chae, YJ., et al. 2015. Pflugers Arch. 467: 1663-76. PMID: 25231973
- Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural Product-Drug Interaction. | Gufford, BT., et al. 2015. Drug Metab Dispos. 43: 1353-9. PMID: 26070840
- Development and validation of ultra-high-performance liquid chromatography-mass spectrometry method for the determination of raloxifene and its phase II metabolites in plasma: Application to pharmacokinetic studies in rats. | Du, T., et al. 2020. J Sep Sci. 43: 4414-4423. PMID: 33119204
- Age-and Region-Dependent Disposition of Raloxifene in Rats. | Du, T., et al. 2021. Pharm Res. 38: 1357-1367. PMID: 34322833
- Evaluation of the major metabolites of raloxifene as modulators of tissue selectivity. | Dodge, JA., et al. 1997. J Steroid Biochem Mol Biol. 61: 97-106. PMID: 9328215
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Raloxifene 4′-Glucuronide, 1 mg | sc-222242 | 1 mg | $411.00 | |||
Raloxifene 4′-Glucuronide, 2 mg | sc-222242A | 2 mg | $681.00 | |||
Raloxifene 4′-Glucuronide, 5 mg | sc-222242B | 5 mg | $1670.00 | |||
Raloxifene 4′-Glucuronide, 10 mg | sc-222242C | 10 mg | $2918.00 |