Ral BP-1 Antibody (H-10): sc-48337

Ral BP-1 Antibody (H-10) is a mouse monoclonal IgG1 antibody that detects Ral BP-1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Ral BP-1 (H-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Ral BP-1 plays a crucial role in cellular signaling pathways, particularly in regulating the Rho family of GTPases, which are essential for various cellular processes such as cytoskeletal dynamics, cell migration, and proliferation. Ral BP-1 contains a Rho-GTPase-activating domain that preferentially interacts with Cdc42, a member of the Rho family, thereby influencing actin cytoskeleton organization and cellular morphology. This interaction maintains normal cellular functions and can have implications in cancer biology, as dysregulation of Ral BP-1 and downstream signaling pathways may contribute to tumorigenesis. Using anti-Ral BP-1 antibody (H-10) in research can provide insights into complex signaling mechanisms involving Ral proteins and their impact on cellular behavior.

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Ral BP-1 Antibody (H-10) References:

1. Identification of membrane-anchoring domains of RLIP76 using deletion mutant analyses.  |  Yadav, S., et al. 2004. Biochemistry. 43: 16243-53. PMID: 15610018
2. RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer.  |  Wang, W., et al. 2018. Cancer Cell. 34: 757-774.e7. PMID: 30423296
3. RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages.  |  Tao, L., et al. 2021. Cell Death Differ. 28: 1418-1433. PMID: 33208891
4. Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1/RIP3-exosome axis.  |  Zeng, X., et al. 2022. Mil Med Res. 9: 25. PMID: 35624495
5. GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1/RIP3/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma.  |  Liu, M., et al. 2022. J Neuroinflammation. 19: 262. PMID: 36289519
6. Inhibition of RIP1 improves immune reconstitution and reduces GVHD mortality while preserving graft-versus-leukemia effects.  |  Prado-Acosta, M., et al. 2023. Sci Transl Med. 15: eadf8366. PMID: 38117900
7. Involvement of Ral GTPase in v-Src-induced phospholipase D activation.  |  Jiang, H., et al. 1995. Nature. 378: 409-12. PMID: 7477381
8. Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases.  |  Cantor, SB., et al. 1995. Mol Cell Biol. 15: 4578-84. PMID: 7623849
9. Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity.  |  Jullien-Flores, V., et al. 1995. J Biol Chem. 270: 22473-7. PMID: 7673236
10. Isolation of cDNA clones and tissue expression of rat ral A and ral B GTP-binding proteins.  |  Wildey, GM., et al. 1993. Biochem Biophys Res Commun. 194: 552-9. PMID: 7687439
11. Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.  |  Spaargaren, M. and Bischoff, JR. 1994. Proc Natl Acad Sci U S A. 91: 12609-13. PMID: 7809086
12. Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.  |  Hofer, F., et al. 1994. Proc Natl Acad Sci U S A. 91: 11089-93. PMID: 7972015

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ral BP-1 Antibody (H-10) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Ral BP-1 Antibody (H-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ral BP-1 Antibody (H-10) Specifications

Alternate Product Name: Ral BP-1

Product Clone Name: H-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 356-655 deletion 581-592

Epitope Target: Ral BP-1

Epitope Species: human

Product Reactivity/Detection: Ral BP-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Ral BP-1 Antibody (H-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin