Rae-1ε Antibody (Y-13B): sc-80311

Rae-1ε Antibody (Y-13B) is a rat monoclonal IgG2a antibody that detects Rae-1ε in mouse and rat samples through flow cytometry (FCM) and enzyme-linked immunosorbent assay (ELISA) applications. Rae-1ε is a crucial ligand for the NKG2D receptor, playing a significant role in the immune response against tumors and infected cells. Rae-1ε is primarily located on the surface of certain tumor cells, where expression is often upregulated, allowing for enhanced recognition and destruction by natural killer (NK) cells. Rae-1ε binding to NKG2D with high affinity is vital for initiating a robust immune response, as this interaction facilitates NK cell activation, which is essential for targeting and eliminating malignant or infected cells. Understanding Rae-1ε expression patterns and interactions is important for developing therapeutic strategies aimed at enhancing anti-tumor immunity, particularly in cancers where NKG2D ligands are exploited by tumors to evade immune detection. Anti-Rae-1ε antibody (Y-13B) is an invaluable tool for researchers investigating the mechanisms of immune evasion and the potential for immunotherapeutic interventions.