Rad51 Antibody (51RAD01): sc-56212
- Rad51 Antibody (51RAD01) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against recombinant Rad51 of human origin
- recommended for detection of Rad51 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See Rad51 (F-11): sc-398587 for Rad51 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Rad51 Antibody (51RAD01). This work is in progress.
Rad51 Antibody (51RAD01) is a mouse monoclonal IgG1 kappa light chain antibody engineered to detect Rad51 protein from mouse, rat, and human origins with exceptional precision in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Rad51 antibody (51RAD01) is raised against recombinant human Rad51, ensuring robust and specific binding to the target antigen. Rad51, also called Reca and Rad51a, is a pivotal protein involved in the homologous recombination repair (HRR) of DNA double-strand breaks, a critical mechanism for maintaining genomic stability and preventing mutations that can lead to cancerous transformations. Functionally, Rad51 facilitates the search for homologous DNA sequences and strand invasion necessary for accurate DNA repair by forming nucleoprotein filaments on DNA, which are essential for these processes. Rad51 interacts closely with key proteins such as BRCA1 and BRCA2, which are integral to the DNA damage response and tumor suppression pathways. The interaction between Rad51 and BRCA2, in particular, is crucial for recruitment and stabilization of Rad51 at sites of DNA damage, enhancing the cell′s ability to repair double-strand breaks effectively. This interaction is vital for preventing genomic instability, a hallmark of many cancers, making Rad51 an important biomarker and target for cancer research and therapeutic interventions. Additionally, Rad51 collaborates with other members of the Rad52 family, including Rad52, Rad54, and MRE11, to coordinate DNA repair and ensure genetic information fidelity. Rad51 monoclonal antibody (51RAD01) enables researchers to accurately study expression, localization, and function of Rad51 in various biological contexts, providing valuable insights into DNA repair mechanisms, molecular basis of cancer development, and cellular responses to DNA damage. Anti-Rad51 antibody (51RAD01) serves as an essential tool in advanced biomedical research and diagnostics, facilitating exploration of novel cancer treatments and understanding of genomic integrity maintenance.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rad51 Antibody (51RAD01) | sc-56212 | 200 µg/ml | $316.00 |