rac-trans-Sertraline (CAS 79836-45-6)

Blood Group Lewis x inhibitors are a class of chemical compounds designed to specifically inhibit the function of the Lewis x antigen, a carbohydrate structure expressed on the surface of various cells, including those in the immune system and epithelial tissues. The Lewis x antigen is a trisaccharide carbohydrate determinant involved in cell-cell recognition processes, including the mediation of adhesion between cells and the extracellular matrix, particularly in the context of immune responses and inflammation. By targeting and inhibiting the Lewis x antigen, these inhibitors can disrupt the interactions that depend on this carbohydrate structure, allowing researchers to explore the mechanisms of cell adhesion, migration, and signaling pathways that are influenced by Lewis x. In scientific research, Blood Group Lewis x inhibitors serve as critical tools for studying the role of glycosylation in biological processes, particularly in understanding how specific carbohydrate structures like Lewis x contribute to cellular communication and immune responses. The use of these inhibitors helps elucidate the role of Lewis x in the modulation of cell behavior, such as leukocyte rolling and extravasation, which are key steps in the immune response and inflammatory processes. Moreover, they provide insights into the significance of carbohydrate antigens in developmental biology, cellular differentiation, and disease progression, where aberrant glycosylation patterns often play a role. By selectively blocking Lewis x, researchers can investigate the downstream effects on cellular processes, offering a deeper understanding of how glycan-mediated interactions contribute to cellular function and the regulation of immune responses. This makes Blood Group Lewis x inhibitors valuable in the field of glycobiology and immunology, where they are used to dissect the complex roles of carbohydrate antigens in health and disease.