Molecular structure of rac-Sitagliptin, CAS Number: 823817-56-7
rac-Sitagliptin (CAS 823817-56-7)
Application:
rac-Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor
CAS Number:
823817-56-7
Molecular Weight:
407.31
Molecular Formula:
C16H15F6N5O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
rac-Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor (DPP-4). DPP-4 is an enzyme which breaks down incretins such as GLP-1, GIP, and gastrointestinal hormones. rac-Sitagliptin controls the release of insulin by inhibiting these gastrointestinal hormones via inhibiting DPP-4. Alternate studies indicate that rac-Sitagliptin can induce hemolysis. Furthermore, rac-Sitagliptin increases the number of insulin-positive β-cells in islets by reducing apoptosis.
rac-Sitagliptin (CAS 823817-56-7) References
- Determination of MK-0431 in human plasma using high turbulence liquid chromatography online extraction and tandem mass spectrometry. | Zeng, W., et al. 2006. Rapid Commun Mass Spectrom. 20: 1169-75. PMID: 16541412
- Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes. | Mu, J., et al. 2006. Diabetes. 55: 1695-704. PMID: 16731832
- Biochar-assisted degradation of oxytetracycline by Achromobacter denitrificans and underlying mechanisms. | Zhang, S., et al. 2023. Bioresour Technol. 387: 129673. PMID: 37579863
Inhibitor of:
CD26.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
rac-Sitagliptin, 1 mg | sc-208294 | 1 mg | $430.00 |