rac Ramelteon-d3 (CAS 1185146-24-0)

Rac Ramelteon-d3, a deuterated analog of Ramelteon, serves as a pivotal tool in the field of chronobiological research, particularly in elucidating the complex mechanisms underlying the regulation of circadian rhythms. Its unique molecular design incorporates deuterium atoms, which, due to their greater mass compared to hydrogen, result in a kinetic isotope effect. This alteration not only extends the molecule′s half-life but also provides a distinctive pharmacokinetic profile, making it an invaluable compound for tracer studies and metabolic pathway analysis. By selectively binding to melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus, Rac Ramelteon-d3 mimics the action of endogenous melatonin, thus offering a profound insight into the molecular governance of sleep-wake cycles and circadian rhythm synchronization. Its application in research facilitates a deeper understanding of these processes at a molecular level, contributing significantly to the field of chronobiology and the study of circadian disorders.