rac Nebivolol-d4 (Major) (CAS 138402-11-6 (unlabeled))

Rac Nebivolol-d4 (Major) is a deuterated version of nebivolol, a β1-adrenergic receptor antagonist, widely used in research to study drug metabolism, receptor binding, and the impact of isotopic labeling on pharmacokinetic properties. The presence of four deuterium atoms in place of hydrogen enhances the compound′s metabolic stability, allowing for a more detailed investigation of its biotransformation and clearance pathways. As a racemic mixture, it contains both active enantiomers, which are crucial in studying stereoselective interactions with biological targets, including the β1-adrenergic receptors. This deuterated compound is particularly valuable in mass spectrometry-based studies, where the deuterium atoms provide a distinctive marker, facilitating the accurate tracking and quantification of the drug in biological samples. Researchers employ rac Nebivolol-d4 (Major) to explore the effects of isotopic substitution on the drug′s binding affinity, distribution, and overall metabolic profile. Additionally, this compound is used to study the potential differences in metabolic pathways between deuterated and non-deuterated versions, providing insights into how isotopic labeling can influence the pharmacokinetic behavior of similar molecules. The use of rac Nebivolol-d4 (Major) in research helps advance the understanding of drug metabolism and the development of more stable and efficacious compounds in various experimental settings.