Rac GAP1 Antibody (B-7): sc-166477
- Rac GAP1 Antibody (B-7) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 142-437 mapping within an internal region of Rac GAP1 of human origin
- recommended for detection of Rac GAP1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG1 BP-HRP is the preferred secondary detection reagent for Rac GAP1 Antibody (B-7) for WB applications. This reagent is now offered in a bundle with Rac GAP1 Antibody (B-7) (see ordering information below).
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Rac GAP1 Antibody (B-7) is a mouse monoclonal IgG1 antibody that detects Rac GAP1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Rac GAP1 antibody (B-7) specifically targets Rac GAP1, also known as MgcRacGAP, ID-GAP, or HsCYK-4, which plays a crucial role in regulating the GTPase activity of Rac1 and Cdc42, two important members of the Ras superfamily of GTP-binding proteins. These proteins are integral to various cellular processes, including growth, vesicle trafficking, and cytoskeletal organization. Rac GAP1 functions as a GTPase-activating protein (GAP), maintaining the balance of active and inactive forms of these GTPases, thereby negatively regulating Ras-mediated signaling pathways. Rac GAP1 is highly expressed in the thymus, placenta, and testis, with lower expression levels found in the spleen and peripheral blood lymphocytes. Structural features include one Rho-GAP domain and a phorbol-ester/DAG-type zinc finger, which are essential for activity and interaction with other proteins. During cytokinesis, Rac GAP1 undergoes phosphorylation at multiple sites, highlighting a dynamic role in cell division and importance in ensuring proper cellular function.
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Rac GAP1 Antibody (B-7) References:
- Rac GTPase activating protein 1 promotes oncogenic progression of epithelial ovarian cancer. | Wang, C., et al. 2018. Cancer Sci. 109: 84-93. PMID: 29095547
- Overexpression of Rac GTPase Activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis. | Yang, XM., et al. 2018. Gastroenterology. 155: 1233-1249.e22. PMID: 30009820
- Rac GTPase-Activating Protein 1 (RACGAP1) as an Oncogenic Enhancer in Esophageal Carcinoma. | Yin, C., et al. 2019. Oncology. 97: 155-163. PMID: 31216559
- Rac GTPase activating protein 1 promotes gallbladder cancer via binding DNA ligase 3 to reduce apoptosis. | Bian, R., et al. 2021. Int J Biol Sci. 17: 2167-2180. PMID: 34239347
- RACGAP1 promotes proliferation and cell cycle progression by regulating CDC25C in cervical cancer cells. | Ruan, X. and Jiang, J. 2022. Tissue Cell. 76: 101804. PMID: 35489195
- RacGAP1 promotes the malignant progression of cervical cancer by regulating AP-1 via miR-192 and p-JNK. | Zhang, T., et al. 2022. Cell Death Dis. 13: 604. PMID: 35831303
- Assessment of RACGAP1 as a Prognostic and Immunological Biomarker in Multiple Human Tumors: A Multiomics Analysis. | Eid, RA., et al. 2022. Int J Mol Sci. 23: PMID: 36430577
- PLAGL2 promotes bladder cancer progression via RACGAP1/RhoA GTPase/YAP1 signaling. | Chen, H., et al. 2023. Cell Death Dis. 14: 433. PMID: 37454211
- Rac GTPase activating protein 1 promotes the glioma growth by regulating the expression of MCM3. | Jia, B., et al. 2023. Transl Oncol. 37: 101756. PMID: 37595394
- Reciprocal regulation between RACGAP1 and AR contributes to endocrine therapy resistance in prostate cancer. | Wang, J., et al. 2024. Cell Commun Signal. 22: 339. PMID: 38898473
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rac GAP1 Antibody (B-7) | sc-166477 | 200 µg/ml | $322.00 | |||
Rac GAP1 Antibody (B-7): m-IgG1 BP-HRP Bundle | sc-542664 | 200 µg Ab; 20 µg BP | $361.00 |