Molecular structure of rac 7-Hydroxy Efavirenz, CAS Number: 205754-50-3
rac 7-Hydroxy Efavirenz (CAS 205754-50-3)
Alternate Names:
6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-7-hydroxy-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
Application:
rac 7-Hydroxy Efavirenz is a non-nucleoside reverse transcriptase inhibitor
CAS Number:
205754-50-3
Molecular Weight:
331.67
Molecular Formula:
C14H9ClF3NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Efavirenz is in the non-nucleoside reverse transcriptase inhibitor (NNRTi) class of antiretrovirals and is used in the treatment of human immunodefiency virus (HIV) type !. A metabolite of Efavirenz (minor).
rac 7-Hydroxy Efavirenz (CAS 205754-50-3) References
- Efavirenz plasma levels for the prediction of treatment failure in heavily pretreated HIV-1 infected patients. | Langmann, P., et al. 2002. Eur J Med Res. 7: 309-14. PMID: 12176680
- Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors. | Ren, J., et al. 2002. Proc Natl Acad Sci U S A. 99: 14410-5. PMID: 12386343
- Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily. | Gorski, JC., et al. 1994. Biochem Pharmacol. 47: 1643-53. PMID: 8185679
- Identification and characterization of human cytochrome P450 isoforms interacting with pimozide. | Desta, Z., et al. 1998. J Pharmacol Exp Ther. 285: 428-37. PMID: 9580580
Inhibitor of:
Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
rac 7-Hydroxy Efavirenz, 1 mg | sc-208269 | 1 mg | $280.00 |