RAB3IP Antibody (B-1): sc-518221
- RAB3IP Antibody (B-1) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 270-295 of RAB3IP of human origin
- recommended for detection of RAB3IP of human origin by WB, IP, IF and ELISA
- Anti-RAB3IP Antibody (B-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP is the preferred secondary detection reagent for RAB3IP Antibody (B-1) for WB applications. This reagent is now offered in a bundle with RAB3IP Antibody (B-1) (see ordering information below).
QUICK LINKS
SEE ALSO...
RAB3IP Antibody (B-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects RAB3IP of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RAB3IP Antibody (B-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RAB3IP, also known as Rabin-3 or SSX2-IP, is a 406 amino acid protein that plays a crucial role in intracellular transport processes, particularly in vesicle movement between the endoplasmic reticulum and Golgi apparatus. RAB3IP facilitates the transport of newly synthesized proteins to designated locations within the cell, making RAB3IP essential for proper secretory pathway function. RAB3IP is expressed in various tissues, including placenta, brain, heart, pancreas, and kidney, and localizes to both nucleus and cytoplasm, existing in multiple alternatively spliced isoforms. RAB3IP interacts with Rab 3A, Rab 3B, and SSX2, which may influence Rab protein function and potentially regulate SSX2-induced malignancies, highlighting RAB3IP′s importance in cellular signaling and disease processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RAB3IP Antibody (B-1) References:
- The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. | de Bruijn, DR., et al. 2002. Genes Chromosomes Cancer. 34: 285-98. PMID: 12007189
- Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion. | Schlüter, OM., et al. 2002. J Biol Chem. 277: 40919-29. PMID: 12167638
- Large scale screening for novel rab effectors reveals unexpected broad Rab binding specificity. | Fukuda, M., et al. 2008. Mol Cell Proteomics. 7: 1031-42. PMID: 18256213
- A different view on DNA amplifications indicates frequent, highly complex, and stable amplicons on 12q13-21 in glioma. | Fischer, U., et al. 2008. Mol Cancer Res. 6: 576-84. PMID: 18403636
- Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A. | Brondyk, WH., et al. 1995. Mol Cell Biol. 15: 1137-43. PMID: 7532276
- Molecular cloning and subcellular localization of three GTP-binding proteins of the rab subfamily. | Olkkonen, VM., et al. 1993. J Cell Sci. 106 (Pt 4): 1249-61. PMID: 8126105
- RAB GTPases expressed in human melanoma cells. | Chen, D., et al. 1997. Biochim Biophys Acta. 1355: 1-6. PMID: 9030196
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RAB3IP Antibody (B-1) | sc-518221 | 200 µg/ml | $316.00 | |||
RAB3IP Antibody (B-1): m-IgG1 BP-HRP Bundle | sc-551326 | 200 µg Ab; 20 µg BP | $354.00 | |||
RAB3IP Antibody (B-1) AC | sc-518221 AC | 500 µg/ml, 25% agarose | $416.00 | |||
RAB3IP Antibody (B-1) HRP | sc-518221 HRP | 200 µg/ml | $316.00 | |||
RAB3IP Antibody (B-1) FITC | sc-518221 FITC | 200 µg/ml | $330.00 | |||
RAB3IP Antibody (B-1) PE | sc-518221 PE | 200 µg/ml | $343.00 | |||
RAB3IP Antibody (B-1) Alexa Fluor® 488 | sc-518221 AF488 | 200 µg/ml | $357.00 | |||
RAB3IP Antibody (B-1) Alexa Fluor® 546 | sc-518221 AF546 | 200 µg/ml | $357.00 | |||
RAB3IP Antibody (B-1) Alexa Fluor® 594 | sc-518221 AF594 | 200 µg/ml | $357.00 | |||
RAB3IP Antibody (B-1) Alexa Fluor® 647 | sc-518221 AF647 | 200 µg/ml | $357.00 | |||
RAB3IP Antibody (B-1) Alexa Fluor® 680 | sc-518221 AF680 | 200 µg/ml | $357.00 | |||
RAB3IP Antibody (B-1) Alexa Fluor® 790 | sc-518221 AF790 | 200 µg/ml | $357.00 |