Rab11-FIP3 Antibody (6H6): sc-517043
- Rab11-FIP3 Antibody (6H6) is a mouse monoclonal IgG2a κ Rab11-FIP3 antibody provided at 100 µg/ml
- raised against amino acids 655-754 representing partial length Rab11-FIP3 of human origin
- recommended for detection of Rab11-FIP3 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Rab11-FIP3 Antibody (6H6). This work is in progress.
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Rab11-FIP3 Antibody (6H6) is a mouse monoclonal IgG2a kappa light chain antibody that detects Rab11-FIP3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Rab11-FIP3 antibody (6H6) is available as a non-conjugated format. Rab11-FIP3, also known as Eferin, is a critical 756 amino acid GTPase-regulating protein that plays a significant role in intracellular trafficking and recycling processes. Rab11-FIP3 contains two EF-hand domains, which are important for calcium binding and signaling, and is primarily localized to recycling endosomes. Such localization facilitates the recycling of membrane proteins and lipids, maintaining cellular homeostasis and function. Rab11-FIP3 forms a heterooligomeric complex with Rab11-FIP4, and within this complex, Rab11-FIP3 interacts with and regulates the functions of Rab 11A, Rab 11B, and Rab 25, which are essential for vesicle transport and docking. Rab11-FIP3 is involved in vesicle docking at the midbody during cytokinesis, highlighting Rab11-FIP3′s importance in cell division and maintaining the structural integrity of the endosomal recycling compartment. This multifaceted role underscores Rab11-FIP3′s significance in cellular processes, making Rab11-FIP3 (6H6) monoclonal antibody a valuable tool for researchers studying endosomal dynamics and GTPase regulation.
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Rab11-FIP3 Antibody (6H6) References:
- Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins. | Prekeris, R., et al. 2001. J Biol Chem. 276: 38966-70. PMID: 11481332
- Identification and characterization of a family of Rab11-interacting proteins. | Hales, CM., et al. 2001. J Biol Chem. 276: 39067-75. PMID: 11495908
- Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells. | Wallace, DM., et al. 2002. Biochem Biophys Res Commun. 299: 770-9. PMID: 12470645
- Rab11-FIP3 localises to a Rab11-positive pericentrosomal compartment during interphase and to the cleavage furrow during cytokinesis. | Horgan, CP., et al. 2004. Biochem Biophys Res Commun. 319: 83-94. PMID: 15158446
- The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis. | Wilson, GM., et al. 2005. Mol Biol Cell. 16: 849-60. PMID: 15601896
- Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. | Fielding, AB., et al. 2005. EMBO J. 24: 3389-99. PMID: 16148947
- Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. | Shiba, T., et al. 2006. Proc Natl Acad Sci U S A. 103: 15416-21. PMID: 17030804
- Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment. | Horgan, CP., et al. 2007. Traffic. 8: 414-30. PMID: 17394487
- Molecular characterization of Rab11-FIP3 binding to ARF GTPases. | Schonteich, E., et al. 2007. Eur J Cell Biol. 86: 417-31. PMID: 17628206
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rab11-FIP3 Antibody (6H6) | sc-517043 | 100 µg/ml | $316.00 |