Rab 8B Antibody (1E4): sc-517045

Rab 8B Antibody (1E4) is a mouse monoclonal IgG2b kappa light chain antibody that detects the Rab 8B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Rab 8B antibody (1E4) is available as a non-conjugated format. Rab 8B, a member of the Ras-related superfamily of guanine nucleotide-binding proteins, plays a crucial role in intracellular transport processes, particularly in the movement of vesicles between the endoplasmic reticulum and the Golgi apparatus. This transport is essential for the proper delivery of newly synthesized proteins to their functional destinations, which is vital for maintaining cellular homeostasis and facilitating neurotransmitter release. Rab 8B consists of 207 amino acids and is characterized by a lipid anchor that localizes to the cytoplasmic side of the cell membrane, allowing interaction with various cellular components involved in vesicular trafficking. Rab 8B is encoded by a gene located on human chromosome 2 and mouse chromosome 9C, and dysfunction has been implicated in various diseases, highlighting the importance of studying Rab 8B in both basic and applied research contexts.

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Rab 8B Antibody (1E4) References:

1. GTP-binding proteins in intracellular transport.  |  Pfeffer, SR. 1992. Trends Cell Biol. 2: 41-6. PMID: 14731525
2. The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach.  |  Chavrier, P., et al. 1992. Gene. 112: 261-4. PMID: 1555775
3. Cloning of a Rab3 isotype predominantly expressed in adipocytes.  |  Baldini, G., et al. 1992. Proc Natl Acad Sci U S A. 89: 5049-52. PMID: 1594612
4. Rab GTPases as coordinators of vesicle traffic.  |  Stenmark, H. 2009. Nat Rev Mol Cell Biol. 10: 513-25. PMID: 19603039
5. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.  |  Zahraoui, A., et al. 1989. J Biol Chem. 264: 12394-401. PMID: 2501306
6. Liver X Receptor Alpha Activation Inhibits Autophagy and Lipophagy in Hepatocytes by Dysregulating Autophagy-Related 4B Cysteine Peptidase and Rab-8B, Reducing Mitochondrial Fuel Oxidation.  |  Kim, YS., et al. 2021. Hepatology. 73: 1307-1326. PMID: 32557804
7. Expression and localization of two low molecular weight GTP-binding proteins, Rab8 and Rab10, by epitope tag.  |  Chen, YT., et al. 1993. Proc Natl Acad Sci U S A. 90: 6508-12. PMID: 7688123
8. Coatomers and SNAREs in promoting membrane traffic.  |  Takizawa, PA. and Malhotra, V. 1993. Cell. 75: 593-6. PMID: 8242734
9. Friends and family: the role of the Rab GTPases in vesicular traffic.  |  Novick, P. and Brennwald, P. 1993. Cell. 75: 597-601. PMID: 8242735
10. The role of GTP-binding proteins in transport along the exocytic pathway.  |  Ferro-Novick, S. and Novick, P. 1993. Annu Rev Cell Biol. 9: 575-99. PMID: 8280472
11. Association of the low molecular weight GTP-binding protein rap2B with the cytoskeleton during platelet aggregation.  |  Torti, M., et al. 1993. Proc Natl Acad Sci U S A. 90: 7553-7. PMID: 8356055
12. Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins.  |  Karniguian, A., et al. 1993. Proc Natl Acad Sci U S A. 90: 7647-51. PMID: 8356066

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Rab 8B Antibody (1E4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Rab 8B Antibody (1E4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Rab 8B Antibody (1E4) Specifications

Alternate Product Name: Rab 8B

Product Clone Name: 1E4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 101-207

Epitope Target: Rab 8B

Epitope Species: human

Product Reactivity/Detection: Rab 8B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Rab 8B Antibody (1E4): N/A