Rab 6A Antibody (38-TB): sc-81913

Rab 6A Antibody (38-TB) is a mouse monoclonal IgG2b kappa light chain antibody that detects Rab 6A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Rab 6A antibody (38-TB) is available as a non-conjugated format. Rab 6A protein plays a crucial role in intracellular transport, particularly in retrograde transport from late endosomes back to endoplasmic reticulum via Golgi apparatus. Rab 6A (38-TB) monoclonal antibody supports research into cellular homeostasis and protein processing pathways. Disruptions in transport mechanisms can lead to various diseases, including neurodegenerative disorders and cancer, highlighting Rab 6A′s importance in cellular function. As a member of Ras-related superfamily of guanine nucleotide-binding proteins, Rab 6A is ubiquitously expressed and essential for both endocytic and biosynthetic pathways. Three isoforms exist due to alternative splicing: widely expressed Rab 6A and Rab 6A′ isoforms, and brain-specific Rab 6B isoform, each contributing to diverse functions in cellular dynamics.

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Rab 6A Antibody (38-TB) References:

1. A role for the Rab6A' GTPase in the inactivation of the Mad2-spindle checkpoint.  |  Miserey-Lenkei, S., et al. 2006. EMBO J. 25: 278-89. PMID: 16395330
2. Rab6A and Rab6A' GTPases play non-overlapping roles in membrane trafficking.  |  Del Nery, E., et al. 2006. Traffic. 7: 394-407. PMID: 16536738
3. Transport of ricin from endosomes to the Golgi apparatus is regulated by Rab6A and Rab6A'.  |  Utskarpen, A., et al. 2006. Traffic. 7: 663-72. PMID: 16683916
4. A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells.  |  Wanschers, BF., et al. 2007. Exp Cell Res. 313: 3408-20. PMID: 17707369
5. Rab6 family proteins interact with the dynein light chain protein DYNLRB1.  |  Wanschers, B., et al. 2008. Cell Motil Cytoskeleton. 65: 183-96. PMID: 18044744
6. Identification of host proteins required for HIV infection through a functional genomic screen.  |  Brass, AL., et al. 2008. Science. 319: 921-6. PMID: 18187620
7. Chromosome assignment of four RAS-related RAB genes.  |  Rousseau-Merck, MF., et al. 1991. Hum Genet. 86: 350-4. PMID: 1999336
8. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.  |  Zahraoui, A., et al. 1989. J Biol Chem. 264: 12394-401. PMID: 2501306

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Rab 6A Antibody (38-TB) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-Rab 6A Antibody (38-TB) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Rab 6A Antibody (38-TB) Specifications

Alternate Product Name: Rab 6A

Product Clone Name: 38-TB

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 109-208

Epitope Target: Rab 6A

Epitope Species: human

Product Reactivity/Detection: Rab 6A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for Rab 6A Antibody (38-TB): N/A