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Rab 42 Antibody (MU-9): sc-130482

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Datasheets
  • Rab 42 Antibody (MU-9) is a mouse monoclonal IgG1 κ Rab 42 antibody provided at 100 µg/ml
  • raised against recombinant Rab 42 of human origin
  • recommended for detection of Rab 42 of human origin by IF and IHC(P)
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Rab 42 Antibody (MU-9). This work is in progress.

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    Rab 42 Antibody (MU-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Rab 42 protein of human origin by immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Rab 42 antibody (MU-9) is available as a non-conjugated format, providing researchers with a versatile tool for studying this important protein. Rab 42, also known as Putative Ras-related protein Rab-42, is a 105 amino acid protein that belongs to the small GTPase superfamily and plays a crucial role in intracellular transport processes. Specifically, Rab 42 regulates vesicle trafficking, which is essential for transporting newly synthesized proteins from the endoplasmic reticulum to the Golgi apparatus and ultimately to secretory vesicles. This function maintains cellular homeostasis and ensures proteins reach their correct destinations, influencing various cellular functions and signaling pathways. The gene encoding Rab 42 is located on chromosome 1, the largest human chromosome, which contains approximately 3,000 genes, many of which are implicated in genetic disorders. Anti-Rab 42 antibody (MU-9) helps researchers gain insights into protein transport dynamics and potential implications of Rab 42 in various diseases, making this antibody an invaluable asset in cellular biology research.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

    Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

    LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

    Rab 42 Antibody (MU-9) References:

    1. The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily.  |  Pereira-Leal, JB. and Seabra, MC. 2000. J Mol Biol. 301: 1077-87. PMID: 10966806
    2. The Rab GTPase family.  |  Stenmark, H. and Olkkonen, VM. 2001. Genome Biol. 2: REVIEWS3007. PMID: 11387043
    3. Evolution of the Rab family of small GTP-binding proteins.  |  Pereira-Leal, JB. and Seabra, MC. 2001. J Mol Biol. 313: 889-901. PMID: 11697911
    4. Rab14 is involved in membrane trafficking between the Golgi complex and endosomes.  |  Junutula, JR., et al. 2004. Mol Biol Cell. 15: 2218-29. PMID: 15004230
    5. Cisternal rab proteins regulate Golgi apparatus redistribution in response to hypotonic stress.  |  Jiang, S. and Storrie, B. 2005. Mol Biol Cell. 16: 2586-96. PMID: 15758030
    6. Vps9 domain-containing proteins: activators of Rab5 GTPases from yeast to neurons.  |  Carney, DS., et al. 2006. Trends Cell Biol. 16: 27-35. PMID: 16330212
    7. The DNA sequence and biological annotation of human chromosome 1.  |  Gregory, SG., et al. 2006. Nature. 441: 315-21. PMID: 16710414
    8. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity.  |  Itoh, T., et al. 2006. Genes Cells. 11: 1023-37. PMID: 16923123
    9. Large scale screening for novel rab effectors reveals unexpected broad Rab binding specificity.  |  Fukuda, M., et al. 2008. Mol Cell Proteomics. 7: 1031-42. PMID: 18256213

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    Rab 42 Antibody (MU-9)

    sc-130482
    100 µg/ml
    $333.00

    Can sc-130482: Rab 42 (MU-9) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

    Asked by: Professor Griffin
    Thank you for your question. Yes, sc-130482: Rab 42 (MU-9) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
    Answered by: Technical Support
    Date published: 2017-03-24
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    Rated 3 out of 5 by from Signal via immunoperoxidase staining of formalinSignal via immunoperoxidase staining of formalin-fixed, paraffin-embedded human colon tissue showing membrane localization.
    Date published: 2013-05-25
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    Rab 42 Antibody (MU-9) is rated 3.0 out of 5 by 1.
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