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Rab 38 Antibody (A-8): sc-390176

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Datasheets
  • Rab 38 Antibody (A-8) is a mouse monoclonal IgG1 κ Rab 38 antibody, cited in 9 publications, provided at 200 µg/ml
  • raised against amino acids 167-211 mapping at the C-terminus of Rab 38 of human origin
  • Rab 38 Antibody (A-8) is recommended for detection of Rab 38 of mouse, rat and human origin by WB, IP, IF and ELISA
  • Anti-Rab 38 Antibody (A-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
  • also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
  • also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
  • m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Rab 38 Antibody (A-8) for WB applications. These reagents are now offered in bundles with Rab 38 Antibody (A-8) (see ordering information below).

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Rab 38 Antibody (A-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects Rab 38 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Rab 38 (A-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Rab 38 protein, also known as rrGTPbp or NY-MEL-1, is a member of the Rab family of proteins, which are part of the Ras-related superfamily of guanine nucleotide-binding proteins. Rab 38 is primarily localized to the cell membrane and plays a crucial role in melanosomal transport and docking, which is essential for melanogenesis—the process of melanin production. Rab 38 protein is particularly important in pigment cell biology, as Rab 38 is involved in the targeting of TRP1, a key protein in melanin synthesis. Mutations in the gene encoding Rab 38 can lead to oculocutaneous albinism (OCA), a genetic condition characterized by a lack of pigment in the skin, hair, and eyes, highlighting the significance of Rab 38 in both cellular transport mechanisms and the maintenance of pigmentation.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

Rab 38 Antibody (A-8) References:

  1. Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library.  |  Jäger, D., et al. 2000. Cancer Res. 60: 3584-91. PMID: 10910072
  2. Mutation of melanosome protein RAB38 in chocolate mice.  |  Loftus, SK., et al. 2002. Proc Natl Acad Sci U S A. 99: 4471-6. PMID: 11917121
  3. Expression and characterization of Rab38, a new member of the Rab small G protein family.  |  Osanai, K., et al. 2005. Biol Chem. 386: 143-53. PMID: 15843158
  4. Melanocyte differentiation antigen RAB38/NY-MEL-1 induces frequent antibody responses exclusively in melanoma patients.  |  Zippelius, A., et al. 2007. Cancer Immunol Immunother. 56: 249-58. PMID: 16718472
  5. Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes.  |  Wasmeier, C., et al. 2006. J Cell Biol. 175: 271-81. PMID: 17043139
  6. Spontaneous CD8 T cell responses against the melanocyte differentiation antigen RAB38/NY-MEL-1 in melanoma patients.  |  Walton, SM., et al. 2006. J Immunol. 177: 8212-8. PMID: 17114498
  7. Analysis of ocular hypopigmentation in Rab38cht/cht mice.  |  Brooks, BP., et al. 2007. Invest Ophthalmol Vis Sci. 48: 3905-13. PMID: 17724166
  8. Analysis and expression of Rab38 in oculocutaneous lung disease.  |  Osanai, K. and Voelker, DR. 2008. Methods Enzymol. 438: 203-15. PMID: 18413250

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Rab 38 Antibody (A-8)

sc-390176
200 µg/ml
$316.00

Rab 38 Antibody (A-8): m-IgGκ BP-HRP Bundle

sc-523434
200 µg Ab, 40 µg BP
$354.00

Rab 38 Antibody (A-8): m-IgG1 BP-HRP Bundle

sc-533582
200 µg Ab; 20 µg BP
$354.00

Rab 38 Antibody (A-8) AC

sc-390176 AC
500 µg/ml, 25% agarose
$416.00

Rab 38 Antibody (A-8) HRP

sc-390176 HRP
200 µg/ml
$316.00

Rab 38 Antibody (A-8) FITC

sc-390176 FITC
200 µg/ml
$330.00

Rab 38 Antibody (A-8) PE

sc-390176 PE
200 µg/ml
$343.00

Rab 38 Antibody (A-8) Alexa Fluor® 488

sc-390176 AF488
200 µg/ml
$357.00

Rab 38 Antibody (A-8) Alexa Fluor® 546

sc-390176 AF546
200 µg/ml
$357.00

Rab 38 Antibody (A-8) Alexa Fluor® 594

sc-390176 AF594
200 µg/ml
$357.00

Rab 38 Antibody (A-8) Alexa Fluor® 647

sc-390176 AF647
200 µg/ml
$357.00

Rab 38 Antibody (A-8) Alexa Fluor® 680

sc-390176 AF680
200 µg/ml
$357.00

Rab 38 Antibody (A-8) Alexa Fluor® 790

sc-390176 AF790
200 µg/ml
$357.00

I need to use an antibody to detect the protein in samples of monkey origin. Do you know if sc-390176: Rab 38 (A-8) mouse monoclonal antibody will work?

Asked by: Trav11
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support
Date published: 2017-03-06
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Rated 5 out of 5 by from Great WB data in AGreat WB data in A-431 whole cell lysate. -SCBT QC
Date published: 2014-05-11
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Rab 38 Antibody (A-8) is rated 5.0 out of 5 by 1.
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