Date published: 2025-10-19

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Rab 33B Antibody (RR-3): sc-81920

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Datasheets
  • Rab 33B Antibody (RR-3) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
  • raised against recombinant Rab 33B of human origin
  • recommended for detection of Rab 33B of mouse, rat and human origin by WB, IP and ELISA
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Rab 33B Antibody (RR-3). This work is in progress.

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    Rab 33B Antibody (RR-3) is a mouse monoclonal IgG2a antibody that detects Rab 33B in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Rab 33B is a crucial member of the Rab family of proteins, which are pivotal in intracellular transport processes, particularly in the movement of vesicles between the endoplasmic reticulum and the Golgi apparatus. Anti-Rab 33B antibody (RR-3) recognizes a protein predominantly localized in the medial-Golgi cisternae, where Rab 33B co-localizes with α-mannosidase II, a well-known Golgi marker, highlighting its role in the biosynthetic pathway. Proper functioning of Rab 33B is essential for maintaining cellular homeostasis, as Rab 33B facilitates the intra-Golgi transport of proteins, ensuring that newly synthesized proteins are correctly processed and dispatched to their final destinations. Additionally, Rab 33B shares conserved effector domains with Rab 33A, indicating potential interactions with similar effector and regulatory proteins, which may further elucidate its role in vesicular trafficking and cellular signaling pathways. Rab 33B monoclonal antibody (RR-3) serves as an invaluable tool for researchers investigating the dynamics of protein transport and the intricate mechanisms of cellular organization.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

    Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

    LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

    Rab 33B Antibody (RR-3) References:

    1. Human SMC2 protein, a core subunit of human condensin complex, is a novel transcriptional target of the WNT signaling pathway and a new therapeutic target.  |  Dávalos, V., et al. 2012. J Biol Chem. 287: 43472-81. PMID: 23095742
    2. Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells.  |  Murakami-Tonami, Y., et al. 2014. Cell Cycle. 13: 1115-31. PMID: 24553121
    3. Condensin Smc2-Smc4 Dimers Are Flexible and Dynamic.  |  Eeftens, JM., et al. 2016. Cell Rep. 14: 1813-8. PMID: 26904946
    4. Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis.  |  Gu, H., et al. 2016. J Clin Invest. 126: 4537-4553. PMID: 27797340
    5. Homotypic and heterotypic trans-assembly of human Rab-family small GTPases in reconstituted membrane tethering.  |  Segawa, K., et al. 2019. J Biol Chem. 294: 7722-7739. PMID: 30910814
    6. Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission.  |  Pandey, R., et al. 2020. Cell Rep. 30: 1883-1897.e6. PMID: 32049018
    7. Intracellular Delivery of Anti-SMC2 Antibodies against Cancer Stem Cells.  |  Montero, S., et al. 2020. Pharmaceutics. 12: PMID: 32098204
    8. Maternal SMC2 is essential for embryonic development via participating chromosome condensation in mice.  |  Xu, K., et al. 2023. J Cell Physiol. 238: 2535-2545. PMID: 37642322
    9. SMC2 knockdown inhibits malignant progression of lung adenocarcinoma by upregulating BTG2 expression.  |  He, Y., et al. 2024. Cell Signal. 120: 111216. PMID: 38729325
    10. Identification of SMC2 and SMC4 as prognostic markers in breast cancer through bioinformatics analysis.  |  Pei, L., et al. 2024. Clin Transl Oncol. 26: 2952-2965. PMID: 38773061

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    Rab 33B Antibody (RR-3)

    sc-81920
    100 µg/ml
    $333.00

    We are potentially interested in your antibody against RAB33B (cat # sc-81920). However, we need it for detection of the mouse protein primarily. Do you know if it cross reacts with the mouse Rab33b? Is a small aliquot available for testing?

    Asked by: Anonymous
    Thank you for your question. This antibody is recommended for detection of RAB33B of mouse, rat and human origin. We do not currently offer a sample size of this antibody. It is available for purchase only.
    Answered by: Technical Support
    Date published: 2020-05-08

    What is the molecular weight of Rab 33B ?

    Asked by: cjMara
    Thank you for your question. Rab 33B has an expected molecular weight of approximately 26 kDa. If you have any questions, please contact our Technical Service Department and we would be happy to assist you.
    Answered by: Technical Support
    Date published: 2017-03-27
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    Rated 4 out of 5 by from Great antibodyGreat antibody, works well with A-431 whole cell lysate. -SCBT QC
    Date published: 2014-07-13
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    Rab 33B Antibody (RR-3) is rated 4.0 out of 5 by 1.
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