Kaiser, et al., Absolute stereochemistry and dopaminergic activity of enantiomers of 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-benzazepine. J. Med. Chem. 25, 697, (1982) Ongini, E., et al., Stimulation of dopamine D1 receptors by SKF-38393 induces EEG desynchronization and behavioral arousal. Life Sci. 37, 2327, (1985) Katz and Witkin., Effects of quinpirole and SKF-38393 alone and in combination in squirrel monkeys trained to discriminate cocaine. Psychopharmacology 107, 217-220, (1992)
Physical State :
Solid
Solubility :
Soluble in 0.1 M HCl, 1.2 mg/mL in ethanol, and 3.4 mg/mL in water
Storage :
Store at room temperature
Optical Activity :
[α]22/D +16.1°, c = 1.2 in methanol(lit.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Elemental analysis within 0.4 of expected result for each element tested
Complies
Identification (Mass Spectrometry)
Electrospray positive analysis shows mass ion corresponding to [M-HCl+H]+
Mass ion: 256.1
NMR
300MHz 1H spectrum in DMSO confirms structure and shows < 1% of any other impurity
Complies
Purity (HPLC)
≥ 99%
> 99%
TLC
2:3 PAW/BuOH; single spot; visualized by UV and KMnO4
Rf = 0.74
Solubility
Soluble in water to 100 mM
Complies
Optical Rotation
11° - 14° at 589 nm in MeOH
+12° (C = 2, in MeOH at 25 °C)
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