Molecular structure of (R,S)-Norcotinine, CAS Number: 17708-87-1
(R,S)-Norcotinine (CAS 17708-87-1)
Application:
(R,S)-Norcotinine is A (±)-Cotinine metabolite
CAS Number:
17708-87-1
Purity:
≥95%
Molecular Weight:
162.19
Molecular Formula:
C9H10N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Norcotinine is often utilized as a reference compound to study nicotine metabolism and to understand the biochemical pathways involved in nicotine breakdown in organisms. It has influence on neurotransmitter activities notably dopamine and norepinephrine. It′s use in environmental monitoring research to trace the exposure and impact of tobacco use in different settings, providing insight into public health studies regarding smoking habits. Furthermore, norcotinine is suggested to inhibit the re-uptake of these neurotransmitters, potentially leading to elevated levels within the brain.
(R,S)-Norcotinine (CAS 17708-87-1) References
- Nornicotine is self-administered intravenously by rats. | Bardo, MT., et al. 1999. Psychopharmacology (Berl). 146: 290-6. PMID: 10541729
- Simultaneous determination of nicotine, cotinine, norcotinine, and trans-3'-hydroxycotinine in human oral fluid using solid phase extraction and gas chromatography-mass spectrometry. | Kim, I., et al. 2005. J Chromatogr B Analyt Technol Biomed Life Sci. 814: 233-40. PMID: 15639444
- A validated method for the determination of nicotine, cotinine, trans-3'-hydroxycotinine, and norcotinine in human plasma using solid-phase extraction and liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. | Kim, I. and Huestis, MA. 2006. J Mass Spectrom. 41: 815-21. PMID: 16705667
- Quantification of nicotine, cotinine, trans-3'-hydroxycotinine, nornicotine and norcotinine in human meconium by liquid chromatography/tandem mass spectrometry. | Gray, TR., et al. 2008. J Chromatogr B Analyt Technol Biomed Life Sci. 863: 107-14. PMID: 18243821
- Simultaneous and sensitive measurement of nicotine, cotinine, trans-3'-hydroxycotinine and norcotinine in human plasma by liquid chromatography-tandem mass spectrometry. | Shakleya, DM. and Huestis, MA. 2009. J Chromatogr B Analyt Technol Biomed Life Sci. 877: 3537-42. PMID: 19748838
- Optimization and validation of a liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of nicotine, cotinine, trans-3'-hydroxycotinine and norcotinine in human oral fluid. | Shakleya, DM. and Huestis, MA. 2009. Anal Bioanal Chem. 395: 2349-57. PMID: 19838828
- A novel validated procedure for the determination of nicotine, eight nicotine metabolites and two minor tobacco alkaloids in human plasma or urine by solid-phase extraction coupled with liquid chromatography-electrospray ionization-tandem mass spectrometry. | Miller, EI., et al. 2010. J Chromatogr B Analyt Technol Biomed Life Sci. 878: 725-37. PMID: 20097626
- Development of an ultrasensitive immunochromatography test to detect nicotine metabolites in oral fluids. | Gonzalez, JM., et al. 2011. Anal Bioanal Chem. 400: 3655-64. PMID: 21556750
- Simultaneous quantification of nicotine and metabolites in rat brain by liquid chromatography-tandem mass spectrometry. | Vieira-Brock, PL., et al. 2011. J Chromatogr B Analyt Technol Biomed Life Sci. 879: 3465-74. PMID: 21963483
- Simultaneous quantification of nicotine, cotinine, trans-3'-hydroxycotinine, norcotinine and mecamylamine in human urine by liquid chromatography-tandem mass spectrometry. | Scheidweiler, KB., et al. 2012. Clin Chim Acta. 413: 978-84. PMID: 22394455
- Simple, fast and sensitive LC-MS/MS analysis for the simultaneous quantification of nicotine and 10 of its major metabolites. | Piller, M., et al. 2014. J Chromatogr B Analyt Technol Biomed Life Sci. 951-952: 7-15. PMID: 24508673
- Simultaneous determination of nicotine and its nine metabolites in rat blood utilizing microdialysis coupled with UPLC-tandem mass spectrometry for pharmacokinetic application. | Mao, J., et al. 2015. Anal Bioanal Chem. 407: 4101-9. PMID: 25824453
- Challenges associated with quantification of selected urinary biomarkers of exposure to tobacco products. | Habibagahi, A., et al. 2021. J Chromatogr B Analyt Technol Biomed Life Sci. 1162: 122490. PMID: 33360416
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(R,S)-Norcotinine, 10 mg | sc-208216 | 10 mg | $286.00 |