Date published: 2025-9-30

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(R,S)-Anabasine-2,4,5,6-d4 (CAS 1020719-08-7)

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Alternate Names:
(R,S)-3-(2-Piperidinyl)pyridine-2,4,5,6-d4
Application:
(R,S)-Anabasine-2,4,5,6-d4 is a nicotinic receptor agonist
CAS Number:
1020719-08-7
Molecular Weight:
164.26
Molecular Formula:
C10H10D4N2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(R,S)-Anabasine-2,4,5,6-d4 is a deuterated analog of anabasine, which itself is a naturally occurring alkaloid found in the tobacco family. This modified compound is particularly valuable in the field of chemical research due to its isotopic labeling with deuterium, replacing hydrogen atoms at specific positions (2, 4, 5, 6). The incorporation of deuterium atoms enhances the molecule′s stability against metabolic degradation, making it an excellent tool for studying the metabolic pathways and biotransformation processes of similar alkaloids through techniques such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. As a chiral compound with both (R) and (S) enantiomers, it allows researchers to explore the stereoselective behavior of biochemical systems, which is for understanding the mechanisms of biologically active substances at a molecular level.


(R,S)-Anabasine-2,4,5,6-d4 (CAS 1020719-08-7) References

  1. A novel validated procedure for the determination of nicotine, eight nicotine metabolites and two minor tobacco alkaloids in human plasma or urine by solid-phase extraction coupled with liquid chromatography-electrospray ionization-tandem mass spectrometry.  |  Miller, EI., et al. 2010. J Chromatogr B Analyt Technol Biomed Life Sci. 878: 725-37. PMID: 20097626
  2. Validation of a LC-MS/MS method for quantifying urinary nicotine, six nicotine metabolites and the minor tobacco alkaloids--anatabine and anabasine--in smokers' urine.  |  McGuffey, JE., et al. 2014. PLoS One. 9: e101816. PMID: 25013964
  3. A comparison of nicotine content methods to produce a UPC2-MS2 method for the analysis of nicotine and minor alkaloids in SPECTRUM nicotine research cigarettes.  |  Carter, RR., et al. 2022. Anal Bioanal Chem. 414: 5817-5828. PMID: 35676561
  4. Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. II. The rundown and inward rectification of agonist-elicited whole-cell currents and identification of receptor subunits by in situ hybridization.  |  Alkondon, M., et al. 1994. J Pharmacol Exp Ther. 271: 494-506. PMID: 7525930
  5. Assembly of human neuronal nicotinic receptor alpha5 subunits with alpha3, beta2, and beta4 subunits.  |  Wang, F., et al. 1996. J Biol Chem. 271: 17656-65. PMID: 8663494
  6. Critical elements determining diversity in agonist binding and desensitization of neuronal nicotinic acetylcholine receptors.  |  Corringer, PJ., et al. 1998. J Neurosci. 18: 648-57. PMID: 9425007

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(R,S)-Anabasine-2,4,5,6-d4, 5 mg

sc-208214
5 mg
$357.00

(R,S)-Anabasine-2,4,5,6-d4, 50 mg

sc-208214A
50 mg
$2458.00