Molecular structure of R,S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt, CAS Number: 52248-03-0
R,S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt (CAS 52248-03-0)
Alternate Names:
SAM p-toluenesulfonate salt
Application:
R,S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt is a methyl donor and cofactor for enzyme-catalyzed methylations
CAS Number:
52248-03-0
Purity:
≥95%
Molecular Weight:
570.645
Molecular Formula:
C15H23N6O5S•C7H7O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
R,S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt combines the bioactive molecule S-Adenosylmethionine (SAMe) with p-toluenesulfonate (tosylate) to enhance its stability and solubility. SAMe itself is a critical biomolecule found in all living cells, where it serves as a major methyl donor in a variety of methylation reactions, essential for numerous metabolic processes. R,S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt is used in studies investigating the biochemical pathways influenced by SAMe and in exploring its potential applications. SAMe is of interest in epigenetics, where changes in DNA methylation patterns can affect gene expression and phenotype. Moreover, the antioxidant and anti-inflammatory roles of compounds synthesized through SAMe-dependent pathways make this molecule relevant in studies on oxidative stress and inflammation.
R,S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt (CAS 52248-03-0) References
- Liquid chromatographic determination of S-adenosyl-L-methionine in dietary supplement tablets. | Zhou, JZ., et al. 2002. J AOAC Int. 85: 901-5. PMID: 12180685
- A general fluorescence-based coupled assay for S-adenosylmethionine-dependent methyltransferases. | Wang, C., et al. 2005. Biochem Biophys Res Commun. 331: 351-6. PMID: 15845399
- S-adenosylmethionine decreases lipopolysaccharide-induced phosphodiesterase 4B2 and attenuates tumor necrosis factor expression via cAMP/protein kinase A pathway. | Gobejishvili, L., et al. 2011. J Pharmacol Exp Ther. 337: 433-43. PMID: 21266552
- A liquid chromatography mass spectrometry method for the measurement of cystathionine β-synthase activity in cell extracts. | Smith, DE., et al. 2012. J Chromatogr B Analyt Technol Biomed Life Sci. 911: 186-91. PMID: 23217323
- S-adenosylmethionine mediates inhibition of inflammatory response and changes in DNA methylation in human macrophages. | Pfalzer, AC., et al. 2014. Physiol Genomics. 46: 617-23. PMID: 25180283
- Discovery and characterization of new O-methyltransferase from the genome of the lignin-degrading fungus Phanerochaete chrysosporium for enhanced lignin degradation. | Thanh Mai Pham, L. and Kim, YH. 2016. Enzyme Microb Technol. 82: 66-73. PMID: 26672450
- Structural basis of 7SK RNA 5'-γ-phosphate methylation and retention by MePCE. | Yang, Y., et al. 2019. Nat Chem Biol. 15: 132-140. PMID: 30559425
- Anti-diabetic effect of S-adenosylmethionine and α-glycerophosphocholine in KK-Ay mice. | Izu, H., et al. 2019. Biosci Biotechnol Biochem. 83: 747-750. PMID: 30582404
- Interactions between Viperin, Vesicle-Associated Membrane Protein A, and Hepatitis C Virus Protein NS5A Modulate Viperin Activity and NS5A Degradation. | Ghosh, S., et al. 2020. Biochemistry. 59: 780-789. PMID: 31977203
- Folate Insufficiency Due to MTHFR Deficiency Is Bypassed by 5-Methyltetrahydrofolate. | Vidmar Golja, M., et al. 2020. J Clin Med. 9: PMID: 32887268
- Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP. | Yang, Y., et al. 2022. Mol Cell. 82: 1724-1736.e7. PMID: 35320752
- Purification of the full-length, membrane-associated form of the antiviral enzyme viperin utilizing nanodiscs. | Patel, AM., et al. 2022. Sci Rep. 12: 11909. PMID: 35831548
- Dietary methionine starvation impairs acute myeloid leukemia progression. | Cunningham, A., et al. 2022. Blood. 140: 2037-2052. PMID: 35984907
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
R,S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt, 25 mg | sc-215827 | 25 mg | $72.00 | |||
R,S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt, 100 mg | sc-215827A | 100 mg | $136.00 | |||
R,S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt, 500 mg | sc-215827B | 500 mg | $622.00 |