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S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt is a methyl donor and cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). While present in all cells, S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt is concentrated in cells liver where 85% of all methylation reactions occur.
Mato, J.M., S-Adenosylmethionine: a control switch that regulates liver function. FASEB J. 16, 15-26, (2002); Villar-Garea, A., and Esteller, M., DNA demethylating agents and chromatin-remodelling drugs: which, how and why?. Curr. Drug Metab. 4, 11-31, (2003)
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