R,S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt CAS: 52248-03-0
MF: C15H23N6O5S•C7H7O3S
MW: 570.645
A methyl donor and cofactor for enzyme-catalyzed methylations.

R,S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt (CAS 52248-03-0)

R,S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt | CAS 52248-03-0 is rated 5.0 out of 5 by 1.
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Synonym: SAM p-toluenesulfonate salt
Application: A methyl donor and cofactor for enzyme-catalyzed methylations
CAS Number: 52248-03-0
Purity: ≥97%
Molecular Weight: 570.645
Molecular Formula: C15H23N6O5S•C7H7O3S
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt is a methyl donor and cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). While present in all cells, S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt is concentrated in cells liver where 85% of all methylation reactions occur.


References

Mato, J.M., S-Adenosylmethionine: a control switch that regulates liver function. FASEB J. 16, 15-26, (2002); Villar-Garea, A., and Esteller, M., DNA demethylating agents and chromatin-remodelling drugs: which, how and why?. Curr. Drug Metab. 4, 11-31, (2003)

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in Water: 100 mg/mL
Storage :
Store at -20° C
Melting Point :
70-90° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10153079
MDL Number :
MFCD00063498
SMILES :
CC1=CC=C(C=C1)S(=O)(=O)[O-].C[S+](CC[[email protected]@H](C(=O)O)N)C[[email protected]@H]1[[email protected]]([[email protected]]([[email protected]@H](O1)N2C=NC3=C2N=CN=C3N)O)O

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Rated 5 out of 5 by from Park Park, J. et al. (PubMed 9022980) constructed a recombinant yeast S-adenosyl-L-methionine (SAM) synthetase strain to generate SAM in situ for use in the multi-enzymatic synthesis of precorrin 2. -SCBT Publication Review
Date published: 2015-03-25
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