Molecular structure of (R,R)-THC, CAS Number: 138090-06-9
(R,R)-THC (CAS 138090-06-9)
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Alternate Names:
(R,R)-cis-Diethyltetrahydro-2,8-chrysenediol; (R,R)-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol
Application:
(R,R)-THC is a selective agonist at ERα and antagonist at ERβ
CAS Number:
138090-06-9
Purity:
≥98%
Molecular Weight:
320.42
Molecular Formula:
C22H24O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(R,R)-THC is a non-steroidal, potent, and selective estrogen receptor (ER) ligand agonist at ERalpha (Ki = 9.0 nM) and antagonist at ERbeta receptor (Ki = 3.6 nM). A recently investigated organochlorine compound called (R,R)-THC has drawn attention for its potential therapeutic uses. Derived from chrysene, a polycyclic aromatic hydrocarbon (PAH) primarily released into the environment through the combustion of fossil fuels and organic matter, (R,R)-THC has exhibited a diverse array of biological effects. Moreover, (R,R)-THC has demonstrated neuroprotective and cardioprotective attributes.
(R,R)-THC (CAS 138090-06-9) References
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- A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle. | Chockalingam, K., et al. 2010. Proc Natl Acad Sci U S A. 107: 3764-9. PMID: 20142494
- Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway. | Guo, AJ., et al. 2011. J Biol Chem. 286: 27882-93. PMID: 21652696
- A pharmacological network for lifespan extension in Caenorhabditis elegans. | Ye, X., et al. 2014. Aging Cell. 13: 206-15. PMID: 24134630
- Estrogen provides neuroprotection against brain edema and blood brain barrier disruption through both estrogen receptors α and β following traumatic brain injury. | Naderi, V., et al. 2015. Iran J Basic Med Sci. 18: 138-44. PMID: 25810887
- [Regulation of uterine blood flow. II. Functions of estrogen and estrogen receptor α/β in genomic and non-genomic actions of the uterine endothelium]. | Mayra, PR., et al. 2014. Rev Chil Obstet Ginecol. 79: 218-228. PMID: 26113751
- Neuroprotection by diarylpropionitrile in mice with spinal cord injury. | Suwanna, N., et al. 2014. EXCLI J. 13: 1097-103. PMID: 26417324
- SIRT1-dependent AMPK pathway in the protection of estrogen against ischemic brain injury. | Guo, JM., et al. 2017. CNS Neurosci Ther. 23: 360-369. PMID: 28256111
- Knockdown of estrogen receptor β increases proliferation and affects the transcriptome of endometrial adenocarcinoma cells. | Treeck, O., et al. 2019. BMC Cancer. 19: 745. PMID: 31357971
- High concentration of estradiol has a negative correlation with free thyroxine during the second trimester of pregnancy. | He, L., et al. 2022. Endocr Connect. 11: PMID: 36006849
- A Novel Resveratrol-Induced Pathway Increases Neuron-Derived Cell Resilience against Oxidative Stress. | Cracco, P., et al. 2023. Int J Mol Sci. 24: PMID: 36982977
- Estrogenic Modulation of Ionic Channels, Pumps and Exchangers in Airway Smooth Muscle. | Romero-Martínez, BS., et al. 2023. Int J Mol Sci. 24: PMID: 37175587
- Role of Estrogen Receptor β, G-Protein Coupled Estrogen Receptor and Estrogen-Related Receptors in Endometrial and Ovarian Cancer. | Schüler-Toprak, S., et al. 2023. Cancers (Basel). 15: PMID: 37345182
Inhibitor of:
ER beta.Activator of:
ER alpha.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(R,R)-THC, 5 mg | sc-204224 | 5 mg | $369.00 | |||
| US: Only available in the US | ||||||
(R,R)-THC, 10 mg | sc-204224A | 10 mg | $629.00 | |||
| US: Only available in the US | ||||||